Detection of Hb A(2) and Hb Constant Spring (HBA2: c.427TC) by Capillary Electrophoresis in a Patient with Hb H-Hb CS Disease

摘要

Hb A(2) (alpha 2 delta 2) is one of the key components looked for in hemoglobinopathies screening programs. Therefore, quantitative and accurate method for Hb A(2) value determination is essential for routine screening. Here, we report a case of Hb A(2) and Hb Constant Spring (Hb CS, HBA2: c.427TC) with Hb H-Hb CS disease that was not detected by high performance liquid chromatography (HPLC), while Hb A(2) and Hb CS were clearly quantified by capillary electrophoresis (CE).