ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats

Chen Yu; Lin Chun; Tang Ying; Chen Ai-Qin; Liu Cui-Ying; Lu Da-Li

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ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats

机译：ZD 7288，HCN通道阻滞剂，抑制肠症状综合征样大鼠的慢性内脏疼痛

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AIM: To investigate the effects of ZD 7288, a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker, on rats with chronic visceral pain.

机译：目的：探讨ZD 7288，一种超极化活化的环状核苷酸门控（HCN）通道阻滞剂对慢性内脏疼痛的大鼠的影响。

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来源
《World journal of gastroenterology :》 |2014年第8期|共7页
作者
Chen Yu; Lin Chun; Tang Ying; Chen Ai-Qin; Liu Cui-Ying; Lu Da-Li;
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作者单位

Fujian Med Univ Dept Physiol &

Pathophysiol Ctr Neurosci Res Lab Pain Res Key Lab Brain Aging &

Fujian Med Univ Dept Physiol &

Pathophysiol Ctr Neurosci Res Lab Pain Res Key Lab Brain Aging &

Fujian Med Univ Dept Physiol &

Pathophysiol Ctr Neurosci Res Lab Pain Res Key Lab Brain Aging &

Fujian Med Univ Dept Physiol &

Pathophysiol Ctr Neurosci Res Lab Pain Res Key Lab Brain Aging &

Fujian Med Univ Dept Physiol &

Pathophysiol Ctr Neurosci Res Lab Pain Res Key Lab Brain Aging &

Fujian Med Univ Dept Physiol &

Pathophysiol Ctr Neurosci Res Lab Pain Res Key Lab Brain Aging &

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原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
Abdominal withdrawal reflex; Electromyography; Hyperpolarization-activated cyclic nucleotide-gated channel; Visceral hypersensitivity; ZD 7288; Irritable bowel syndrome;

机译：腹部戒断反射;肌电图;超极化激活的循环核苷酸门控通道;内感超敏;ZD 7288;肠易激综合征;

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1. ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats [J] . Chen Yu, Lin Chun, Tang Ying, World journal of gastroenterology : . 2014,第8期

机译：ZD 7288，HCN通道阻滞剂，抑制肠症状综合征样大鼠的慢性内脏疼痛
2. Blockage of HCN Channels with ZD7288 Attenuates Mechanical Hypersensitivity in Rats Model of Diabetic Neuropathy [J] . Hussain Abdulaziz Alturki, Abdulmalik Abdulaziz Alkhamis, Abdulaziz Mohammed AlEessa, The Egyptian Journal of Hospital Medicine . 2018,第12期

机译：HCN通道堵塞具有ZD7288的HCN通道衰减大鼠糖尿病神经病变的大鼠模型中的机械超敏反应
3. Effects of ZD7288, a hyperpolarization-activated cyclic nucleotide gated (HCN) channel blocker, on term-pregnant rat uterine contractility in vitro [J] . Theriogenology . 2017,第期

机译：ZD7288，一种超极化活性循环核苷酸门控（HCN）通道阻断剂在体外术语术语大鼠子宫收缩性
4. The Effects of Wumei Pill on Intestinal Flora and Neurotransmitters in Rats with Diarrhea-predominant Irritable Bowel Syndrome (IBS-D) [C] . Xiaojie Ding, Xiling Sun, Xiaofei Yu, International Conference on Biotechnology and Bioengineering . 2019

机译：尿布丸对腹泻的肠道菌群和神经递质的影响（IBS-D）
5. Lactobacillus reuteri reduces visceral hypersensitivity and alters gut motility without changing gut serotonin availability in an animal model of the irritable bowel syndrome. [D] . Jakupovic, Jasmina. 2013

机译：在肠易激综合征的动物模型中，路氏乳杆菌可降低内脏超敏反应并改变肠蠕动，而不会改变肠内5-羟色胺的利用率。
6. ZD 7288 an HCN channel blocker attenuates chronic visceral pain in irritable bowel syndrome-like rats [O] . Yu Chen, Chun Lin, Ying Tang, 2014

机译：ZD 7288是一种HCN通道阻滞剂可减轻肠易激综合征样大鼠的慢性内脏痛
7. ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats [O] . Yu Chen 2014

机译：ZD 7288，HCN通道阻滞剂，衰减肠道综合征样大鼠的慢性内脏疼痛

ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats

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