Intrahepatic V gamma 9V delta 2 T-cells from HCV-infected patients show an exhausted phenotype but can inhibit HCV replication

摘要

Hepatitis C virus (HCV) persistence results from inefficiencies of both innate and adaptive immune responses to eradicate the infection. A functional impairment of circulating V gamma 9V delta 2 T-cells was described but few data are available on V gamma 9V delta 2 T-cells in the liver that, however, represents the battlefield in the HCV/host interaction.