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Changes in the tissue concentrations of several neuropeptides in porcine intestines and intestine-innervating ganglia in the course of porcine proliferative enteropathy

机译:在猪增殖肠病过程中猪肠内肠肠和内肠道神经节的几种神经肽组织浓度的变化

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Inflammatory processes are associated with changes in the interplay of different pro-and anti-inflammatory factors, including neuropeptides, in tissue. This study was performed to investigate the influence of proliferative enteropathy on the concentration of several neuropeptides known to be involved in the regulation of the inflammatory process in porcine intestine and intestine-innervating ganglia. The concentration of galanin, vasoactive intestinal polypeptide, somatostatin, neuropeptide Y, substance P and calcitonin gene-related peptide were assayed with ELISA in the coeliac-superior mesenteric ganglion, inferior mesenteric ganglion, selected dorsal root ganglia, ileum and the descending colon in healthy and sick pigs. The concentrations of the studied neuropeptides were higher in sick animals. Statistically significant differences were found for coeliac-superior mesenteric ganglion (galanin, vasoactive intestinal polypeptide, somatostatin and neuropeptide Y), inferior mesenteric ganglion (galanin, somatostatin and neuropeptide Y), dorsal root ganglia (galanin, somatostatin, neuropeptide Y and calcitonin gene-related peptide), ileum (galanin and somatostatin) and the descending colon (galanin, somatostatin and neuropeptide Y). The data clearly show the influence of the inflammatory process on the concentration of some of the studied neuropeptides present in inflamed tissues and ganglia innervating the inflamed gut. These changes must be associated with the role the studied neuropeptides play in the inflammatory process.
机译:炎症过程与不同亲和抗炎因子的相互作用的变化有关,包括组织中神经肽。进行该研究以研究增殖性肠球病的影响对已知涉及猪肠和肠道内神经节的炎症过程调节的几种神经肽的浓度。在腹腔 - 优质的肠系膜神经节,较差的肠系膜神经节,选择背根神经节,回肠和健康中,用ELISA测定环肽素,血管活性γ,物质P和降钙素基因相关肽的浓度。生病的猪。病人的神经肽的浓度在生病的动物中较高。对腹腔 - 优质肠系膜神经节(环肽,血管活性肠道多肽,生长抑制素和神经肽Y),下肠系膜神经节(环肽,生长抑素和神经肽Y),背根神经节(甘肽,生长抑素,神经肽Y和降钙素基因 - 相关肽),回肠(Galanin和Somatostatin)和下降结肠(甘醇,生长抑素和神经疏皮y)。数据清楚地表明炎症过程对发炎组织和神经节的一些研究中的一些研究神经肽的浓度的影响。这些变化必须与所研究的神经肽在炎症过程中发挥作用的作用相关。

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