Excretion and toxicity evaluation of I-131-Sennoside A as a necrosis-avid agent

摘要

1. Sennoside A (SA) is a newly identified necrosis-avid agent that shows capability for imaging diagnosis and tumor necrosis targeted radiotherapy. As a water-soluble compound, I-131-Sennoside A (I-131-SA) might be excreted predominately through the kidneys with the possibility of nephrotoxicity.