Study on the correlation between adipocyte fatty‐acid binding protein, glucolipid metabolism, and pre‐eclampsia

摘要

Abstract Aim We aimed to explore the relation between the level of adipocyte fatty‐acid binding protein (A‐FABP) in the gestational period and related indices of glucolipid metabolism, and the possible mechanisms of occurrence and development of pre‐eclampsia. Methods Seventy‐six pre‐eclampsia patients were enrolled and divided into the mild pre‐eclampsia ( n ?=?42) and severe pre‐eclampsia ( n ?=?34) groups. Forty‐eight healthy pregnant women were selected as a control group. The indices of all participants were examined, including serum A‐FABP, fasting insulin (FINS), fasting blood glucose, total cholesterol (TC), triglycerides (TG), low‐density lipoprotein (LDL), and high‐density lipoprotein (HDL), and homeostatic model assessment insulin resistance (HOMA‐IR) index was calculated. After the delivery of the placenta, the level of A‐FABP in the placenta was detected by immunochemistry. Then, the correlation between serum A‐FABP and indices of glucolipid metabolism and placental A‐FABP were analyzed. Results Serum A‐FABP, FINS, TG, TC, HOMA‐IR, and placental A‐FABP were significantly higher in pre‐eclampsia patients and the level of HDL was obviously lower than in the control group. Serum A‐FABP was positively correlated with FINS, TG, TC, and HOMA‐IR, and placental A‐FABP was negatively correlated with HDL in pre‐eclampsia patients. In the control group, serum A‐FABP was positively correlated only with TG, and uncorrelated with the other indices ( P ??0.05). Conclusion The level of A‐FABP was correlated with insulin resistance and indices of glucolipid metabolism in pre‐eclampsia patients. High‐levels of A‐FABP might increase insulin resistance by causing glucose and lipid metabolism disorders and ultimately inducing the occurrence and development of pre‐eclampsia.