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首页> 外文期刊>The journal of gene medicine >Multivalent methionine‐functionalized biocompatible block copolymers for targeted small interfering RNA delivery and subsequent reversal effect on adriamycin resistance in human breast cancer cell line MCF‐7/ADR
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Multivalent methionine‐functionalized biocompatible block copolymers for targeted small interfering RNA delivery and subsequent reversal effect on adriamycin resistance in human breast cancer cell line MCF‐7/ADR

机译：用于靶向小干扰RNA递送的多价甲硫氨酸官能化生物相容性嵌段共聚物及对人乳腺癌细胞系MCF-7 / ADR中亚霉素抗性的随后的逆转作用

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Abstract <section xml:id="jgm2969-sec-0001" numbered="no"> <title type="main">Background >Cationic polymers are outstanding representatives of the most efficient small interfering RNA (siRNA) vectors. Low cytotoxicity and siRNA protecting effect can be obtained with these cationic polymers via a variety of structural modifications. Nevertheless, the gap between their efficiency and the requirement for therapeutic processes is still noticeable. </section> <section xml:id="jgm2969-sec-0002" numbered="no"> <title type="main">Methods > A cationic polymer vector was synthesized via the copolymerization of <fi>N</fi> ‐(1,3‐dihydroxy propan‐2‐yl)methacrylamide (DHPMA) and <fi>N</fi> ‐(3‐aminopropyl)methacrylamide (APMA). </section> <section xml:id="jgm2969-sec-0003" numbered="no"> <title type="main">Results > APMA provides amine functionality that allows the conjugation of guanidine and methionine groups. Attributed to the hydroxy groups of DHPMA, the synthesized guanidine and methionine grafted DHPMA <fi>‐b‐</fi> APMA block copolymer (mDG) is water soluble and has good biocompatibility. The obtained mDG has high zeta potential, narrow molecular weight distribution, better membrane‐penetrating ability, high transfection efficiency, tumor cell targeting ability and high stability. </section> <section xml:id="jgm2969-sec-0004" numbered="no"> <title type="main">Conclusions >The synthesized polymer vector can deliver siRNA molecules into tumor cells and then reverse drug resistance by down regulation of P‐glycoprotein mRNA expression. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”> <title type =“main”>抽象</ title> <section XML：ID =“JGM2969-SEC-0001 “编号=”否“> <标题类型=”main“>背景</ title> >阳离子聚合物是最有效的小干扰RNA（siRNA）载体的优异代表。通过各种结构改性，可以通过这些阳离子聚合物获得低细胞毒性和siRNA保护效果。尽管如此，它们的效率与治疗过程的要求仍然明显。</ p> </ section> <secto xml：id =“jgm2969-sec-0002”编号=“no”> <title type =“main “>方法</标题> >通过<fi> n-fl-（1,3-二羟基丙烷-2-基）甲基丙烯酰胺（DHPMA）和<FI> N合成阳离子聚合物载体。 </ Fi> - （3-氨基丙基）甲基丙烯酰胺（APMA）。 </ p> </ section> <section XML：ID =“JGM2969-SEC-0003”编号=“否”> <标题类型=“main”>结果</ title> > apma提供允许的胺功能胍和甲硫氨酸基团的缀合。归因于DHPMA的羟基，合成的胍和甲硫氨酸接枝DHPMA <FI> -B - </ FI> APMS嵌段共聚物（MDG）是水溶性并且具有良好的生物相容性。所获得的MDG具有高Zeta电位，分子量分布，更好的膜穿透能力，高转染效率，肿瘤细胞靶向能力和高稳定性。 </ p> </段> <部分XML：ID =“JGM2969-SEC-0004”编号=“否”> <标题类型=“main”>结论</标题> >合成的聚合物载体可以递送siRNA分子进入肿瘤细胞，然后通过对糖蛋白mRNA表达的下调调节逆转耐药性。</ p> </段> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-30882/'>《The journal of gene medicine》</a> <b style="margin: 0 2px;">|</b><span>2017年第8期</span><b style="margin: 0 2px;">|</b><span>共1页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Yang&option=202" target="_blank" rel="nofollow">Wu Yang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Wei&option=202" target="_blank" rel="nofollow">Zhang Wei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Tinghan&option=202" target="_blank" rel="nofollow">Li Tinghan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ma Rong&option=202" target="_blank" rel="nofollow">Ma Rong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Dan&option=202" target="_blank" rel="nofollow">Chen Dan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Junying&option=202" target="_blank" rel="nofollow">Zhang Junying;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Jianzhong&option=202" target="_blank" rel="nofollow">Wu Jianzhong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tang Jinhai&option=202" target="_blank" rel="nofollow">Tang Jinhai;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Research Center of Clinical OncologyJiangsu Cancer Hospital Jiangsu Institute of Cancer Research Nanjing Medical University Affiliated Cancer HospitalNanjing China;</p> <p>Collaborative Innovation Center of Suzhou Nano Science and TechnologySoutheast UniversityNanjing China;</p> <p>Jiangsu Key Laboratory of Drug Design and Optimization and Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing China;</p> <p>Research Center of Clinical OncologyJiangsu Cancer Hospital Jiangsu Institute of Cancer Research Nanjing Medical University Affiliated Cancer HospitalNanjing China;</p> <p>Research Center of Clinical OncologyJiangsu Cancer Hospital Jiangsu Institute of Cancer Research Nanjing Medical University Affiliated Cancer HospitalNanjing China;</p> <p>Research Center of Clinical OncologyJiangsu Cancer Hospital Jiangsu Institute of Cancer Research Nanjing Medical University Affiliated Cancer HospitalNanjing China;</p> <p>Research Center of Clinical OncologyJiangsu Cancer Hospital Jiangsu Institute of Cancer Research Nanjing Medical University Affiliated Cancer HospitalNanjing China;</p> <p>Department of General Surgerythe First Affiliated Hospital with Nanjing Medical UniversityNanjing China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1473.html" title="医学遗传学">医学遗传学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=gene delivery&option=203" rel="nofollow">gene delivery;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=P glycoprotein&option=203" rel="nofollow">P glycoprotein;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=RAFT polymerization&option=203" rel="nofollow">RAFT polymerization;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=siRNA&option=203" rel="nofollow">siRNA;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=tumor targeting&option=203" rel="nofollow">tumor targeting;</a> </p> <div class="translation"> 机译：基因递送;p糖蛋白;筏聚合;siRNA;肿瘤靶向; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704024826611.html">Multivalent methionine‐functionalized biocompatible block copolymers for targeted small interfering RNA delivery and subsequent reversal effect on adriamycin resistance in human breast cancer cell line MCF‐7/ADR</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Yang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wu Yang,</a> <a 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auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：Ophiobolin-O通过抗阿霉素的人乳腺癌细胞（MCF-7 / ADR）的细胞周期阻滞和凋亡敏化作用逆转阿霉素的耐药性。</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/0100099526936.html ">Ophiobolin-O Reverses Adriamycin Resistance via Cell Cycle Arrest and Apoptosis Sensitization in Adriamycin-Resistant Human Breast Carcinoma (MCF-7/ADR) Cells</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Weiming Zhu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Weiming Zhu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Caiguo Huang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Caiguo Huang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kui Hong&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kui Hong,</a> <span>2013</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：Ophiobolin-O通过细胞周期阻滞和阿霉素抗性人乳腺癌（mCF-7 / aDR）细胞凋亡增敏逆转阿霉素耐药性</span> </p> </li> <li> <div> <b>8. </b><a class="enjiyixqcontent" href="/ntis-science-report_ad_thesis/02071511268.html">Reversal of Doxorubicin Resistance in Human Breast Adenocarcinoma (MCF- 7) Cells by Liposomal Monensin</a> <b>[R] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sachdeva, M. 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S. </a> <span>2005</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：脂质体莫能菌素逆转人乳腺癌（mCF-7）细胞中多柔比星的耐药性</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-breast-disease-electronic-edition_thesis/0201236755869.html">小分子干扰RNA联合反义脱氧寡核苷酸靶向逆转人乳腺癌细胞MCF-7/ADR多药耐药的研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=魏军民&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 魏军民</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=侯明&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,侯明</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李丽珍&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李丽珍</a> <span> <a 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