Biomolecular MRI reporters: Evolution of new mechanisms

Arnab Mukherjee; Hunter C. Davis; Pradeep Ramesh; George J. Lu; Mikhail G. Shapiro

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Biomolecular MRI reporters: Evolution of new mechanisms

机译：生物分子MRI记者：新机制的演变

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?Biomolecular reporters are essential to enable MR imaging of cellular function.

?Several breakthrough concepts in biomolecular MRI reporters were recently developed.

?Water channel proteins serve as reporter genes for diffusion-weighted imaging.

?Gas-filled proteins produce contrast in hyperpolarized129Xe MRI.

?Peptides altering blood flow produce locally enhanced hemodynamic contrast.

Abstract

Magnetic resonance imaging (MRI) is a powerful te

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？生物分子记者对于启用蜂窝函数的MR成像至关重要。

？生物分子MRI记者的几个突破性概念我们最近开发的。

？水通道蛋白作为分散加权成像的报告基因。

？填充蛋白质在超极化中产生对比度 129 xe mri 。

？改变血液流动的肽会产生局部增强的血液动力学对比。

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磁共振成像（MRI）是一个强大的te

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来源
《Progress in Nuclear Magnetic Resonance Spectroscopy: An International Review Journal》 |2017年第2017期|共11页
作者
Arnab Mukherjee; Hunter C. Davis; Pradeep Ramesh; George J. Lu; Mikhail G. Shapiro;
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作者单位

Division of Chemistry and Chemical Engineering California Institute of Technology;

Division of Chemistry and Chemical Engineering California Institute of Technology;

Division of Biology and Biological Engineering California Institute of Technology;

Division of Chemistry and Chemical Engineering California Institute of Technology;

Division of Chemistry and Chemical Engineering California Institute of Technology;

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原文格式 PDF
正文语种 eng
中图分类光谱学;
关键词
Magnetic resonance imaging (MRI); Contrast agents; Biomolecular reporters; Diffusion; Hyperpolarization;

机译：磁共振成像（MRI）;造影剂;生物分子记者;扩散;超极化;

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1. Biomolecular MRI reporters: Evolution of new mechanisms [J] . Arnab Mukherjee, Hunter C. Davis, Pradeep Ramesh, Progress in Nuclear Magnetic Resonance Spectroscopy: An International Review Journal . 2017,第期

机译：生物分子MRI记者：新机制的演变
2. MRI CEST at 1T With Large mu(eff) Ln(3+) Complexes T m(3+)-HPDO3A: An Efficient MRI pH Reporter [J] . Rancan Giaime, Castelli Daniela Delli, Aime Silvio Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine . 2016,第1期

机译：具有大mu（eff）Ln（3+）配合物T m（3 +）-HPDO3A的1T MRI CEST：高效的MRI pH报告器
3. Role of Water Molecules in Protein-Ligand Dissociation and Selectivity Discrimination: Analysis of the Mechanisms and Kinetics of Biomolecular Solvation Using Molecular Dynamics [J] . Huefner-Wulsdorf Tobias, Klebe Gerhard Journal of chemical information and modeling . 2020,第3期

机译：水分子在蛋白质 - 配体解离和选择性辨别中的作用：使用分子动力学分析生物分子溶剂的机制和动力学
4. Biomolecular motor-based cargo transporters with loading/unloading mechanisms on a micro-patterned DNA array [C] . Hiyama S., Takeuchi S., Gojo R., IEEE International Conference on Micro Electro Mechanical Systems . 2008

机译：基于生物分子电机的货物运输车，在微图案化DNA阵列上装载/卸载机制
5. The Enhancement of NMR/MRI Signals for Medical Imaging and Biomolecular Study. [D] . Zhang, Boyang. 2013

机译：用于医学成像和生物分子研究的NMR / MRI信号增强。
6. Biomolecular MRI Reporters: evolution of new mechanisms [O] . Arnab Mukherjee, Hunter C. Davis, Pradeep Ramesh, -1

机译：生物分子MRI记者：新机制的演变
7. Splicing Reporter Mice Revealed the Evolutionally Conserved Switching Mechanism of Tissue-Specific Alternative Exon Selection [O] . Takeuchi, Akihide, Hosokawa, Motoyasu, Nojima, Takayuki, 2010

机译：剪接记者小鼠揭示了组织选择性替代外显子选择的进化保守切换机制。

Biomolecular MRI reporters: Evolution of new mechanisms

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