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Preparation and characterization of chitosan based hydrogels containing cyclodextrin inclusion compounds or nanoemulsions of thyme oil

机译：含有环糊精包合物或百里香油纳米乳液的壳聚糖基水凝胶的制备与表征

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Abstract >Hydrogels derived from natural polysaccharides are ideal scaffolds for use in biomedical applications. pH‐sensitive polyvinyl alcohol and chitosan hydrogels containing inclusion compounds of thyme oil (TM) with host methyl‐β‐cyclodextrin (MβCD) and hydroxypropyl‐β‐cyclodextrin (HβCD) and TM nanoemulsion (TM‐nano) were prepared via controlled, biocompatible and low cost freeze–thaw method. The structure of the hydrogels was characterized by Fourier transform IR spectroscopy and optical and scanning electron microscopy. The physicochemical properties of the hydrogels such as gel fraction, swelling ratio and tensile properties were measured. The water vapor transmission rate of the hydrogels indicated that they can maintain a moist environment over the wound bed. Encapsulation and release of antibacterial TM from the hydrogels were determined by UV spectroscopy. In all cases, hydrogels with lower amounts of TM evidenced slower and more controlled release. Different kinetic models were applied for evaluating the drug release mechanism. The antibacterial activity of the samples was studied by counting the number of both Gram‐negative and Gram‐positive bacteria surviving in a broth medium and the results proved the antibacterial activity of all prepared hydrogels. The results of an MTT (3‐(4,5‐dimethylthiazol‐2yl)‐2,5‐diphenyltetrazolium bromide) assay indicated more cell viability of TM‐nano hydrogels in comparison with those of TM‐βCD inclusion compounds. Cell attachment observations also showed great biocompatibility of TM‐nano hydrogels. The prepared hydrogels, especially those containing TM‐nano, might be used as potential wound dressings to improve the wound healing process. ? 2019 Society of Chemical Industry </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> 来自天然多糖的水凝胶是用于生物医学应用的理想支架。通过受控，生物相容性制备含有宿主甲基-β-环糊精（MβCD）和羟丙基-β-环糊精（HβCD）和TM纳米乳剂（TM纳米乳剂（TM纳米乳剂（TM纳米）的含有百合油（TM）包涵体（TM）的含有百里香油（TM）的壳聚糖水凝胶。和低成本的冻融方法。通过傅里叶变换IR光谱和光学和扫描电子显微镜表征水凝胶的结构。测定了水凝胶的物理化学性质，例如凝胶分数，溶胀比和拉伸性质。水凝胶的水蒸气透射率表明它们可以在伤口床上保持潮湿的环境。通过UV光谱法测定来自水凝胶的抗菌TM的封装和释放。在所有情况下，具有较低TM的水凝胶可以证明较慢和更控制的释放。应用不同的动力学模型来评估药物释放机制。通过计算肉汤中存活的革兰氏阴性和革兰氏阳性细菌的数量来研究样品的抗菌活性，结果证明了所有制备的水凝胶的抗菌活性。 MTT（3-（4,5-二甲基噻唑-200L）-2,5-二苯基四唑鎓溴化物）测定的结果表明了与TM-βCD包容化合物相比的TM-NANO水凝胶的细胞活力更多。细胞附着观察还显示出TM-Nano水凝胶的巨大生物相容性。制备的水凝胶，尤其是含有Tm-Nano的水凝胶，可用作潜在的伤口敷料，以改善伤口愈合过程。还2019年化学工业学会</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-29710/'>《Polymer international》</a> <b style="margin: 0 2px;">|</b><span>2019年第11期</span><b style="margin: 0 2px;">|</b><span>共12页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Moradi Sara&option=202" target="_blank" rel="nofollow">Moradi Sara;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Barati Abolfazl&option=202" target="_blank" rel="nofollow">Barati Abolfazl;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Salehi Ehsan&option=202" target="_blank" rel="nofollow">Salehi Ehsan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tonelli Alan E&option=202" target="_blank" rel="nofollow">Tonelli Alan E;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hamedi Hamid&option=202" target="_blank" rel="nofollow">Hamedi Hamid;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Chemical Engineering Faculty of EngineeringArak UniversityArak Markazi Iran;</p> <p>Department of Chemical Engineering Faculty of EngineeringArak UniversityArak Markazi Iran;</p> <p>Department of Chemical Engineering Faculty of EngineeringArak UniversityArak Markazi Iran;</p> <p>Fiber and Polymer Science Program Textile Engineering Chemistry and Science Department College of TextilesNorth Carolina State UniversityRaleigh NC USA;</p> <p>Fiber and Polymer Science Program Textile Engineering Chemistry and Science Department College of TextilesNorth Carolina State UniversityRaleigh NC USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1185.html" title="高分子化学（高聚物）">高分子化学（高聚物）;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=wound dressings&option=203" rel="nofollow">wound dressings;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=chitosan&option=203" rel="nofollow">chitosan;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=thyme oil nanoemulsions&option=203" rel="nofollow">thyme oil nanoemulsions;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cyclodextrin inclusion compounds&option=203" rel="nofollow">cyclodextrin inclusion compounds;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=antibacterial activity&option=203" rel="nofollow">antibacterial activity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=drug delivery&option=203" rel="nofollow">drug delivery;</a> </p> <div class="translation"> 机译：伤口敷料;壳聚糖;百里香油纳米乳液;环糊精包衣化合物;抗菌活性;药物递送; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704024575095.html">Preparation and characterization of chitosan based hydrogels containing cyclodextrin inclusion compounds or nanoemulsions of thyme oil</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Moradi Sara&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Moradi Sara,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Barati Abolfazl&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Barati Abolfazl,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Salehi Ehsan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Salehi Ehsan,</a> <a href="/journal-foreign-29710/" target="_blank" rel="nofollow" class="tuijian_authcolor">Polymer international .</a> <span>2019</span><span>,第11期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：含有环糊精包合物或百里香油纳米乳液的壳聚糖基水凝胶的制备与表征</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_food-hydrocolloids_thesis/0204121693072.html">Preparation and characterization of gellan gum-chitosan polyelectrolyte complex films with the incorporation of thyme essential oil nanoemulsion</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Xinhui&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zhang Xinhui,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Donghong&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Liu Donghong,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jin Tony Z.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jin Tony Z.,</a> <a href="/journal-foreign-2359/" target="_blank" rel="nofollow" class="tuijian_authcolor">Food Hydrocolloids .</a> <span>2021</span><span>,第May期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：Gellan Gum-Chotosan聚电解质复合膜与百里香精油纳米乳液掺入的制备与表征</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_detail_thesis/0204120843764.html">Preparation and Characterization of Chitosan–Alginate Polyelectrolyte Complexes Loaded with Antibacterial Thyme Oil Nanoemulsions</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hamid Hamedi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hamid Hamedi,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sara Moradi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sara Moradi,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Alan E. 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