Self-organization in physical and biological systems Comment on 'Morphogenesis as Bayesian inference: A variational approach to pattern formation and control in complex biological systems' by Franz Kuchling et al.

摘要

The paper by Kuchling et al. [9] presents cellular morphogenesis as a self-organizing process in light of the min-imization of the free energy of the system. The FEP principle has been gaining in popularity and is handling quite complex issues in biology as evidenced by the numerous other publications cited in this review paper alone. The FEP sits on a rigorous mathematical foundation and the computations are quite impressive. The comments presented here are focused, however on its connections to physics, including existing theories of non-equilibrium thermodynamics which have proven to be successful as well as some underlying philosophical issues.