AgBF4 catalyzed regio- and stereoselective synthesis of trans alpha-vinyl-beta-amino esters via asymmetric addition of siyl dienolate to sulfinylimines

摘要

AgBF4 catalyzed Mannich-type reactions of siyl dienolate with chiral aryl-substituted (S)-N-tert-butanesulfinylimines has been developed. A class of chiral trans -vinyl--amino esters was obtained in moderate to excellent yields (up to 93%), good diastereoselectiveties (up to 92:8 dr), and complete -site regioselectivity.