Combination of BMSCs‐laden acellular nerve xenografts transplantation and G‐CSF administration promotes sciatic nerve regeneration

Jia Hua; Wang Ying; Chen Jiao; Li Jun‐Ping; Han Huai‐Qin; Tong Xiao‐Jie; He Zhong‐Yi; Ma Wen‐Zhi

摘要

Abstract > Peripheral nerve gaps often lead to interrupted innervation, manifesting as severe sensory and motor dysfunctions. The repairs of the nerve injuries have not achieved satisfactory curative effects in clinic. The transplantation of bone marrow stromal cells (BMSCs)‐laden acellular nerve xenografts (ANX) has been proven more effective than the acellular nerve allografting. Besides, granulocyte colony‐stimulating factor (G‐CSF) can inhibit inflammation and apoptosis, and thus is conducive to the microenvironmental improvement of axonal regeneration. This study aims to investigate the joint effect of BMSCs‐seeded ANX grafting and G‐CSF administration, and explore the relevant mechanisms. Adult SD rats were divided into five groups randomly: ANX group, ANX combined with G‐CSF group, BMSCs‐laden ANX group, BMSCs‐laden ANX combined with G‐CSF group, and autograft group. Eight?weeks after transplantation, the detection of praxiology and neuroelectrophysiology was conducted, and then the morphology of the regenerated nerves was analyzed. The inflammatory response and apoptosis in the nerve grafts as well as the expression of the growth‐promoting factors in the regenerated tissues were further assayed. G‐CSF intervention and BMSCs implanting synergistically promoted peripheral nerve regeneration and functional recovery following ANX bridging, and the restoration effect was matchable with that of the autologous nerve grafting. Moreover, local inflammation was alleviated, the apoptosis of the seeded BMSCs was decreased, and the levels of the neuromodulatory factors were elevated. In conclusion, the union application of BMSCs‐implanted ANX and G‐CSF ameliorated the niche of neurotization and advanced nerve regeneration substantially. The strategy achieved the favorable effectiveness as an alternative to the autotran </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：ID =“Syn22093-Abs-0001”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >外围神经间隙常常导致中断的内窥镜，表现为严重的感官和电动机功能障碍。神经损伤的修复在临床上没有令人满意的疗效作用。骨髓基质细胞（BMSCs） - 甲苯细胞神经异种移植物（AX）的移植已被证明比无细胞神经同种异体更有效。此外，粒细胞菌落刺激因子（G-CSF）可以抑制炎症和细胞凋亡，从而有利于轴突再生的微环境改善。本研究旨在探讨BMSCS种子嫁接和G-CSF管理的关节作用，探讨相关机制。成人 SD </ i>大鼠随机分为五组：ANX Group，CAM结合G-CSF组，BMSCs-Laden ANX Group，BMSCS-Laden焦虑与G-CSF组，以及自体移植组。移植后八周，进行了海洋病变和神经电生理学的检测，然后分析了再生神经的形态。进一步测定神经移植物中炎症反应和细胞凋亡以及再生组织中生长促进因子的表达。 G-CSF干预和BMSCs植入协同促进的外周神经再生和功能恢复后的交易桥接后，恢复效果与自体神经移植的恢复效果相匹配。此外，减轻了局部炎症，降低了种子BMSCs的凋亡，神经调节因子的水平升高。总之，BMSCS植入的愈合症和G-CSF的联盟应用改善了神经化和高级神经再生的利基。该战略达到了有利的效果，作为Autotran的替代品 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-28762/'>《Synapse》</a> <b style="margin: 0 2px;">|</b><span>2019年第7期</span><b style="margin: 0 2px;">|</b><span>共15页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jia Hua&option=202" target="_blank" rel="nofollow">Jia Hua;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Ying&option=202" target="_blank" rel="nofollow">Wang Ying;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Jiao&option=202" target="_blank" rel="nofollow">Chen Jiao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Jun‐Ping&option=202" target="_blank" rel="nofollow">Li Jun‐Ping;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Han Huai‐Qin&option=202" target="_blank" rel="nofollow">Han Huai‐Qin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tong Xiao‐Jie&option=202" target="_blank" rel="nofollow">Tong Xiao‐Jie;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=He Zhong‐Yi&option=202" target="_blank" rel="nofollow">He Zhong‐Yi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ma Wen‐Zhi&option=202" target="_blank" rel="nofollow">Ma Wen‐Zhi;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Human Anatomy and Histoembryology College of Basic Medical SciencesNingxia Medical UniversityYinchuan China;</p> <p>Research Institute of Neural Tissue Engineering Department of AnatomyMudanjiang College of MedicineMudanjiang China;</p> <p>Department of Human Anatomy and Histoembryology College of Basic Medical SciencesNingxia Medical UniversityYinchuan China;</p> <p>Department of Human Anatomy and Histoembryology College of Basic Medical SciencesNingxia Medical UniversityYinchuan China;</p> <p>Department of Human Anatomy and Histoembryology College of Basic Medical SciencesNingxia Medical UniversityYinchuan China;</p> <p>Department of Anatomy College of Basic Medical SciencesChina Medical UniversityShenyang China;</p> <p>Department of Human Anatomy and Histoembryology College of Basic Medical SciencesNingxia Medical UniversityYinchuan China;</p> <p>Department of Human Anatomy and Histoembryology College of Basic Medical SciencesNingxia Medical UniversityYinchuan China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/200.html" title="神经病学与精神病学">神经病学与精神病学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=acellular nerve xenograft&option=203" rel="nofollow">acellular nerve xenograft;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=bone marrow stromal cells&option=203" rel="nofollow">bone marrow stromal cells;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=granulocyte colony‐stimulating factor&option=203" rel="nofollow">granulocyte colony‐stimulating factor;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=peripheral nerve regeneration&option=203" rel="nofollow">peripheral nerve regeneration;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=transplantation&option=203" rel="nofollow">transplantation;</a> </p> <div class="translation"> 机译：细胞神经异种移植物;骨髓基质细胞;粒细胞菌落刺激因子;周围神经再生;移植; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704024355486.html">Combination of BMSCs‐laden acellular nerve xenografts transplantation and G‐CSF administration promotes sciatic nerve regeneration</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jia Hua&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jia Hua,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Ying&option=202" target="_blank" rel="nofollow" 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L.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li, Z.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Li, Z. </a> <span>2017</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：使用脱细胞神经同种异体移植物加羊水来源的干细胞（aFs）加速大间隙周围神经损伤的再生。</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-rehabilitation-theory-practice_thesis/0201278383224.html">内源性神经营养因子促进冷冻保存大鼠坐骨神经异体移植后神经再生的作用</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张松&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张松</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄英如&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,黄英如</a> <a 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href="/academic-journal-cn_journal-binzhou-medical-university_thesis/0201243575896.html">神经干细胞移植对脊髓创伤后神经再生促进作用的研究进展</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨大伟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 杨大伟</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=靳春杰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,靳春杰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吕苓甫&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,吕苓甫</a> <span> <a href="/journal-cn-6472/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 滨州医学院学报 </a> </span> <span> . 2014</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-6025_thesis/020221578483.html">仿生外周神经支架携载PLGA微球缓释FK506促进大鼠坐骨神经再生的实验研究</a> <b>[C]</b> <span> <a 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