Stem cell culture differentiation and transplantable biodegradable microporous micropatterned nerve guidance conduit for nerve regeneration and biodegradable microporous micropatterned nerve guidance conduit manufactured thereby

摘要

The present invention relates to a method of manufacturing a bio-degradable porous micropattern nerve conduit and a bio-degradable porous micropattern nerve conduit manufactured through the same, capable of etching micropatterns through capillary force lithography (CFL) using capillary power, manufacturing a patch having a porous surface through salt leaching, and forming a conduit through a rolling method. The present invention provides a method of manufacturing a degradable porous polymer micropattern patch for the culture and transplantation of stem cells, and a degradable porous polymer micropattern patch for the culture and transplantation of stem cells, which is manufactured through the method. The bio-degradable porous micropattern nerve conduit of the present invention is capable of having a high clinical application possibility by improving interaction with existing nerve tissue to expect quick fusion in an affected area, and also, having a high possibility to be applied to a nerve conduit, in which stem cells are easily cultured and transplanted, for controlling a neuroaxonal direction during the culture of the stem cells.