Preoperative Geriatric Nutritional Risk Index: A predictive and prognostic factor in patients with pathological stage I non-small cell lung cancer

摘要

Abstract Background Surgical outcomes of early-stage non-small cell lung cancer (NSCLC) are poor. The Geriatric Nutritional Risk Index (GNRI) is a useful parameter for evaluating nutritional status. We aimed to investigate if preoperative GNRI could be a predictive factor for pathological stage I NSCLC patients. Patients and methods We retrospectively selected 141 consecutive pathological stage I NSCLC patients treated from August 2005 to August 2010. We analyzed their preoperative GNRI in univariate and multivariate Cox regression analyses for postoperative recurrence-free survival (RFS). Results A preoperative abnormal GNRI was significantly associated with postoperative recurrence ( P ?=?0.0107). Univariate analyses showed that serum carcinoembryonic antigen (CEA) levels ( P ?=?0.0013), preoperative serum albumin level ( P ? P ?=?0.0009), pleural invasion ( P ? P ?=?0.0137) significantly affected RFS. In multivariate analysis, preoperative GNRI ( P ?=?0.0084), CEA level ( P ?=?0.0031), preoperative serum albumin level ( P ?=?0.0041) and pleural invasion ( P ?=?0.0018) were independent prognostic factors. In Kaplan–Meier analysis of RFS, cancer-specific survival (CS), and overall survival (OS) by preoperative GNRI, the abnormal GNRI group had significantly shorter RFS, CS, and OS (5-year RFS, CS, and OS: 52.81% vs. 89.15%; P ? P ?=?0.0014 and 50.84% vs. 89.57%; P ? Conclusions Preoperative GNRI is a novel prognostic factor for pathological stage I NSCLC patients, which can identify high-risk patients for postoperative recurrence and cancer-related death. Highlights ? The GNRI is based on two parameters including serum albumin and body weight. ? We analyzed p-stage I NSCLC patients to investigate effects of preoperative GNRI. ? Preoperative GNRI was significantly associated with postoperative recurrence. ? Preoperative abnormal GNRI group had significantly shorter RFS, CS, and OS. ? Preoperative GNRI is a simple and novel prognostic factor.