DETERMINATION OF THE RISK OF DISTANT METASTASES IN SURGICALLY TREATED PATIENTS WITH NON-SMALL CELL LUNG CANCER IN STAGE I-IIIA

摘要

The invention relates to a method of determination of the risk of distant metastases in surgically treated patients with non-small cell lung cancer in stage I-IIIA wherein microRNA is extracted from a sample of primary tumor tissue, retrotranscribed into complementary DNA by reverse transcription, quantity of microRNA hsa-miR-660 is examined with the use of quantitative PCR method and the expression value of this microRNA is referred to the corresponding microRNA reference expression values in a disease recurrence prediction model in which low expression value of microRNA hsa-miR-660 is correlated to the high risk of distant metastases.