MicroRNA-based classifiers for diagnosis of oral cavity squamous cell carcinoma in tissue and plasma

Pedersen Nicklas Juel; Jensen David Hebbelstrup; Lelkaitis Giedrius; Kiss Katalin; Charabi Birgitte Wittenborg; Ullum Henrik; Specht Lena; Schmidt Ane Yde; Nielsen Finn Cilius; von Buchwalda Christian

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MicroRNA-based classifiers for diagnosis of oral cavity squamous cell carcinoma in tissue and plasma

机译：基于MicroRNA的组织和等离子体口腔鳞状细胞癌的基于MicroRNA的分类器

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Background: MicroRNAs (miRNAs) hold promise as diagnostic cancer biomarkers. Here we aimed to define the miRNome in oral squamous cell carcinoma (OSCC) and normal oral mucosa (NOM), and to identify and validate new diagnostic miRNAs and miRNA combinations in formalin-fixed paraffin-embedded (FFPE) tissue samples and plasma samples.

机译：背景：MicroRNA（miRNA）将承诺作为诊断癌症生物标志物。在这里，我们旨在在口腔鳞状细胞癌（OSCC）和正常口腔粘膜（NOM）中定义MiRNOME，并鉴定和验证新的诊断miRNA和MiRNA组合在福尔马林固定的石蜡包埋（FFPE）组织样品和血浆样品中。

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来源
《Oral oncology》 |2018年第2018期|共7页
作者
Pedersen Nicklas Juel; Jensen David Hebbelstrup; Lelkaitis Giedrius; Kiss Katalin; Charabi Birgitte Wittenborg; Ullum Henrik; Specht Lena; Schmidt Ane Yde; Nielsen Finn Cilius; von Buchwalda Christian;
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作者单位

Univ Copenhagen Rigshosp Dept Otorhinolaryngol Head &

Neck Surg &

Audiol Copenhagen Denmark;

Univ Copenhagen Rigshosp Dept Otorhinolaryngol Head &

Neck Surg &

Audiol Copenhagen Denmark;

Univ Copenhagen Rigshosp Dept Pathol Copenhagen Denmark;

Univ Copenhagen Rigshosp Dept Pathol Copenhagen Denmark;

Univ Copenhagen Rigshosp Dept Otorhinolaryngol Head &

Neck Surg &

Audiol Copenhagen Denmark;

Univ Copenhagen Rigshosp Dept Clin Immunol Copenhagen Denmark;

Univ Copenhagen Rigshosp Dept Oncol Copenhagen Denmark;

Univ Copenhagen Rigshosp Ctr Genom Med Copenhagen Denmark;

Univ Copenhagen Rigshosp Ctr Genom Med Copenhagen Denmark;

Univ Copenhagen Rigshosp Dept Otorhinolaryngol Head &

Neck Surg &

Audiol Copenhagen Denmark;

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原文格式 PDF
正文语种 eng
中图分类耳鼻咽喉科学;
关键词
Oral squamous cell carcinoma; Biomarker; Plasma; miRNA; REMARK guidelines; miRNome;

机译：口腔鳞状细胞癌;生物标志物;等离子体;miRNA;备注指南;mirnome;

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专利

1. MicroRNA-based classifiers for diagnosis of oral cavity squamous cell carcinoma in tissue and plasma [J] . Pedersen Nicklas Juel, Jensen David Hebbelstrup, Lelkaitis Giedrius, Oral oncology . 2018,第期

机译：基于MicroRNA的组织和等离子体口腔鳞状细胞癌的基于MicroRNA的分类器
2. Peritumoral cuffing by T-cell tumor-infiltrating lymphocytes distinguishes HPV-related oropharyngeal squamous cell carcinoma from oral cavity squamous cell carcinoma [J] . Poropatich Kate, Hernandez David, Fontanarosa Joel, Journal of oral pathology and medicine: Official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology . 2017,第10期

机译：T细胞肿瘤浸润淋巴细胞的蠕动抑制区分HPV相关的口咽鳞状细胞癌免受口腔鳞状细胞癌
3. Automatic identification of clinically relevant regions from oral tissue histological images for oral squamous cell carcinoma diagnosis [J] . Das Dev Kumar, Bose Surajit, Maiti Asok Kumar, Tissue and Cell . 2018,第期

机译：从口腔鳞状细胞癌诊断中口服组织组织学图像自动识别临床相关地区
4. In-vivo fluorescence detection and imaging of porphyrin-producing bacteria in the human skin and in the oral cavity for diagnosis of acne vulgaris caries and squamous cell carcinoma [C] . Karsten Koenig, Herbert Schneckenburger, Joerg Hemmer, Conference on the use of optical spectroscopy for disease diagnosis . 1994

机译：人体皮肤和口腔中卟啉产生细菌的体内荧光检测和成像，用于诊断痤疮祛痘龋齿和鳞状细胞癌
5. The correlation between tumour volume and survival in oral cavity and oropharyngeal squamous cell carcinoma. [D] . Anand, Sumeet M. 2009

机译：口腔和口咽鳞状细胞癌的肿瘤体积与生存率的关系。
6. An oral cavity squamous cell carcinoma quantitative histomorphometric-based image classifier of nuclear morphology can risk stratify patients for disease-specific survival [O] . Cheng Lu, James S Lewis Jr, William D Dupont, -1

机译：基于口腔鳞状细胞癌定量组织形态学的核形态学图像分类器可能会使患者的疾病特异性存活风险分层
7. An oral cavity squamous cell carcinoma quantitative histomorphometric-based image classifier of nuclear morphology can risk stratify patients for disease-specific survival [O] . Cheng Lu, James S Lewis, William D Dupont, 2017

机译：核形态学的口腔鳞状细胞癌定量组织形态学图像分类器可以风险分层患者患者特异性生存率
8. Combined Therapy for Non-Resectable Squamous Cell Carcinoma of the Oral Cavity. Local Selective Intra-Arterial Infusion with Adriamycin and Bleomycin Combined Concurrently with Radiotherapy. The Predictive Value of Flow Cytometry in Monitoring Cell Cycle Kinetic Effects of Therapy [R] . Noorman van der Dussen, M. F. 1986

机译：口腔不可切除鳞状细胞癌的联合治疗。局部选择性动脉内注射阿霉素和博来霉素联合放疗。流式细胞术在监测细胞周期动力学疗效中的预测价值

MicroRNA-based classifiers for diagnosis of oral cavity squamous cell carcinoma in tissue and plasma

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