CRISPR GENOME SURGERY IN THE RETINA IN LIGHT OF OFF-TARGETING

摘要

Purpose: Recent concerns regarding the clinical utilization of clustered regularly interspaced short palindromic repeats (CRISPR) involve uncertainties about the potential detrimental effects that many arise due to unintended genetic changes, as in off-target mutagenesis, during CRISPR genome surgery. This review gives an overview of offtargeting detection methods and CRISPR's place in the clinical setting, specifically in the field of ophthalmology.