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首页> 外文期刊>Regulatory Toxicology and Pharmacology: RTP >Updating the evidence relating smoking bans to incidence of heart disease
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Updating the evidence relating smoking bans to incidence of heart disease

机译:更新将吸烟禁止的证据更新到心脏病发病率

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摘要

In our latest update of the evidence on smoking bans and heart disease we summarize 59 studies. We take account of the underlying trends in incidence rates as far as possible by using control data in eight studies, and by adjustment based on observed trends in cases pre- and post-ban in 40 studies, being unable to make an adjustment in the remaining 11 studies. Overall, based on 62 independent estimates from the 59 studies, we estimate that bans reduce incidence by 5.0% (95% CI 3.2-6.8%), though this estimate reduces to 2.9% (0.01-5.6%) when we exclude regional estimates where national estimates are available, and studies where trend adjustment is not possible. For 25 of the studies, quadratic rather than linear adjustment is possible, but this hardly affects the overall estimates. Ban effects are somewhat greater when the pre-ban period studied is relatively short, and in smaller studies. We compare our findings with those in other recent reviews, one of which totally ignored underlying trends and results from control populations. We discuss reasons why we believe there is likely to be a true small effect of smoking bans, and weaknesses in the data which preclude reaching any very confident conclusion.
机译:在我们最新更新关于吸烟禁烟和心脏病的证据,我们总结了59项研究。我们考虑到八项研究中的控制数据尽可能尽可能地考虑到发病率的潜在趋势,并根据在40项研究中预先禁止和禁止后的观察到趋势的调整,无法在剩余时间内进行调整11研究。总体而言,基于59项研究的62个独立估计,我们估计禁止将发病率降低5.0%(95%CI 3.2-6.8%),但是当我们排除区域估计数时,这一估计减少到2.9%(0.01-5.6%)可用国家估计数,并无法进行趋势调整的研究。对于25项研究,可以进行二次而不是线性调整,但这几乎不会影响整体估计。当研究的预禁令时期相对较短,在较小的研究中,禁令效果有些更大。我们将我们的调查结果与其他近期点评的调查结果进行比较,其中一个人完全忽略了控制人口的潜在趋势和结果。我们讨论了为什么我们认为可能是吸烟禁令的真正小效的原因,以及妨碍达到任何非常自信的结论的数据中的缺点。

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