Computational Studies of N-substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors using 3D-QSAR, Pharmacophore Modeling and Molecular Docking

摘要

Background: Acquired immunodeficiency syndrome is a disease derive from infection of human immunodeficiency virus, and integrase is an important target for antiviral drugs. N-substituted quinolinonyl diketo acid derivatives as integrase strand transfer inhibitors were investigated in this work to discuss the relationships between chemical structures and their bioactivities.