Design, Synthesis and in silico Studies of New 5-substituted-2-(2-(5-aryl-1H-1,2,4-triazole-3-ylthio) acetyl) Hydrazine Carbothioamide/Carboxamides for Anticonvulsant Activity

摘要

Background: Research on the synthesis of anticonvulsants is still in progress as they produce adverse effects with lesser activity as well as the patients become resistant to drug therapy. 1,2,4-triazole scaffold is a resource for the synthesis of anticonvulsant agents having better pharmacological action. Virtual Screening plays an important role to achieve binding affinity, receptor and library pre-processing, docking, scoring and top scoring hits. Optimization of drug ADME parameters continues to play an important role to achieve proof of concept, and ultimately efficacy, safely in clinical trials to address unmet medical need.