Photosensitizers for antibacterial photodynamic therapy based on tetracationic derivatives of synthetic bacteriochlorins

摘要

Antibacterial photodynamic therapy is a promising method of treating local infected foci, in particular, surgical and burn wounds, trophic and diabetic ulcers. Both Gram-positive bacteria Staphylococcus aureus and Grain-negative bacteria Pseudomonas aeruginosa are found in most infected wounds. Photodynamic inactivation (PDI) is able to effectively destroy bacterial cells without developing resistance in response to treatment. This work is dedicated to the study of photophysical and antibacterial properties of new photosensitizers based on tetracationic synthetic bacteriochlorins with a reduced size of the molecule and molecular weight for PDI of S. aureus and P. aeruginosa bacteria and their biofilms.