Photosensitizers based on derivatives bacteriochlorin P, a process for producing bacteriochlorin P AND METHOD photodynamic therapy CANCER WITH THE USE OF THIS photosensitizer

摘要

1. The photosensitizer, which is a nanostructured aqueous dispersion based bacteriochlorin derivative p, wherein p bacteriochlorin derivative is the methyl ester O-ethyloxime N-p C38H46N6O6 etoksitsikloimida bacteriochlorin having the structural formula: ! 2. A photosensitizer of claim 1 characterized in that the nanostructured aqueous dispersion is a dispersion based on liposome lecithin and cholesterol, and methyl O-ethyloxime N-p etoksitsikloimida bacteriochlorin incorporated into the lipid bilayer of liposomes. ! 3. The photosensitizer according to claim 1, characterized in that the nanostructured aqueous dispersion is a dispersion having a micellar surfactant - a block copolymer of oxyethylene and oxypropylene. ! 4. A photosensitizer of claim 1 characterized in that the nanostructured aqueous dispersion is a nanoemulsion based Cremophor. ! 5. A method for producing O-methyl N-ethyloxime etoksitsikloimida bacteriochlorin p, a strong nucleophile comprising exposing the solution to a bacteriochlorophyll derivative of a, characterized by the fact that as a solution of a bacteriochlorophyll derivative as used bakteriopurpurina methyl ester in a basic solvent (pyridine or any other organic solvent with the addition of organic base to neutralize the hydrochloric acid) as a strong nucleophile ethoxyamine hydrochloride are used, taken in 1.5-fold excess, p eaktsiyu carried out at room temperature for 72-80 hours and is complete after absorption maximum displacement reaction mixture to 802 nm. ! 6. The method fotodinamich