Preparation of 2,5-diamino-1,3,4-thiadiazole derivatives using MgO nanoparticles as heterogeneous basic catalysts

摘要

The synthesis of 2,5-diamino-1,3,4-thiadiazole derivatives was performed via the reaction of dithiocarbamate derivatives and hydrazine sulfate in presence of MgO nanoparticles as heterogeneous catalysts, which were prepared by the sol-gel method. The pure products were produced in a simple and clean method in presence of MgO nanoparticles (5mg) in the refluxing water (0.5cm(3)) around 10h with good-to-excellent yields (up to 95%). The prepared metal oxide nanoparticles were characterized by powder X-ray diffraction, scanning electron microscopy, energy dispersive X-ray, and Fourier transform infrared spectroscopy.