The effect of combination oral contraceptives on smoking-related symptomatology during short-term smoking abstinence

摘要

Although an estimated 25% of premenopausal smokers report using oral contraceptives (OC), little is known about how OC use may influence smoking cessation. The purpose of this study was to examine the difference in smoking-related symptomatology during acute smoking abstinence between women on a standardized combination DC (Tri-Sprintec (TM)) compared to women not on OCs (no-DC). Participants were women aged 18-40 who smoked >= 5 cigarettes/day and reported regular menstrual cycles. Using a controlled cross-over design, participants completed two six-day testing weeks: Low Progesterone Week (LPW; Follicular (F) phase in no-OC or 1st week of pills in DC) and High Progesterone Week (HPW; Luteal (L) phase in no-DC or 3rd week of pills in OC). Each testing week included daily assessment of symptomatology and biochemical confirmation of smoking status.