No Longer Hidden Secrets of Proton Pumping: The Resolution Revolution Enlightens V-ATPases

摘要

In this issue of Molecular Cell, Roh et al. (2018) present a high-resolution cryo-EM structure of the nanodiscreconstituted yeast Vo proton channel that provides important new insights into subunit arrangements and the proton translocation pathway in V-type ATPases.