On water noncatalytic tandem Knoevenagel-Michael reaction of aldehydes, N,N '-dimethylbarbituric acid and cyclohexane-1,3-diones

摘要

Heating aldehydes, NX-dimethylbarbituric acid and cyclohexane-1,3-diones in water results in fast formation of Knoevenagel-Michael adducts in 82-98% yields. This multicomponent process opens facile, efficient and environmentally benign way to the new functionalized [(2-hydroxy-6oxocyclohex-1-en-1-y1)(aryHmethylIpyrimidine-2,4(1H,3H)diones bearing both barbituric acid and cyclohexane-1,3-dione moieties separated by arylmethylene spacer, which are promising compounds for biomedical applications including analeptics, anti-AIDS and anticancer remedies.