The impact of antiandrogen flutamide on the hypoxia inducible factor 1 alpha and vascular endothelial growth factor A gene and protein expression in the pig placenta during late pregnancy

摘要

Introduction. In contrast to estradiol action, little is known about androgen signaling in placental development. The purpose of this study was to evaluate the impact of diminished androgen action on hypoxia inducible factor 1 alpha (HIF-1 alpha) and vascular endothelial growth factor A (VEGFA) protein expression as well as their mRNAs in the structures of fetal and maternal parts of porcine placenta during late pregnancy.