Challenges in clinical implementation of CYP2D6 genotyping: choice of variants to test affects phenotype determination

Hoshitsuki Keito; Crews Kristine R.; Yang Wenjian; Smith Colton A.; Hankins Jane S.; Turner Amy J.; Broeckel Ulrich; McMillin Gwendolyn A.; Relling Mary V.; Haidar Cyrine E.

首页> 外文期刊>Genetics in medicine >Challenges in clinical implementation of CYP2D6 genotyping: choice of variants to test affects phenotype determination

【24h】

Challenges in clinical implementation of CYP2D6 genotyping: choice of variants to test affects phenotype determination

机译：CYP2D6基因分型临床实施中临床实施的挑战：测试变体的选择会影响表型测定

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

著录项
相似文献
相关主题

著录项

来源
《Genetics in medicine》 |2020年第1期|共2页
作者
Hoshitsuki Keito; Crews Kristine R.; Yang Wenjian; Smith Colton A.; Hankins Jane S.; Turner Amy J.; Broeckel Ulrich; McMillin Gwendolyn A.; Relling Mary V.; Haidar Cyrine E.;
展开▼
作者单位

St Jude Childrens Res Hosp Dept Pharmaceut Sci 332 N Lauderdale St Memphis TN 38105 USA;

St Jude Childrens Res Hosp Dept Pharmaceut Sci 332 N Lauderdale St Memphis TN 38105 USA;

St Jude Childrens Res Hosp Dept Pharmaceut Sci 332 N Lauderdale St Memphis TN 38105 USA;

St Jude Childrens Res Hosp Dept Pharmaceut Sci 332 N Lauderdale St Memphis TN 38105 USA;

St Jude Childrens Res Hosp Dept Hematol 332 N Lauderdale St Memphis TN 38105 USA;

RPRD Diagnost LLC Milwaukee WI USA;

RPRD Diagnost LLC Milwaukee WI USA;

Univ Utah Salt Lake City UT USA;

St Jude Childrens Res Hosp Dept Pharmaceut Sci 332 N Lauderdale St Memphis TN 38105 USA;

St Jude Childrens Res Hosp Dept Pharmaceut Sci 332 N Lauderdale St Memphis TN 38105 USA;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医学遗传学;
关键词

相似文献

外文文献
中文文献
专利

1. Challenges in clinical implementation of CYP2D6 genotyping: choice of variants to test affects phenotype determination [J] . Hoshitsuki Keito, Crews Kristine R., Yang Wenjian, Genetics in medicine . 2020,第1期

机译：CYP2D6基因分型临床实施中临床实施的挑战：测试变体的选择会影响表型测定
2. DETERMINATION OF CYP2D6 PHENOTYPING FOR METOPROLOL USING THE CYP2D6 GENOTYPE-DERIVED ACTIVITY SCORE: RESULTS FROM A PROSPECTIVE, CLINICAL TRIAL. [J] . Thomas C. D., Mosley S. A., El Rouby N., Clinical Pharmacology and Therapeutics . 2019,第Suppla1期

机译：使用CYP2D6基因型衍生活动评分测定甲金属托洛尔的CYP2D6表型：结果来自前瞻性，临床试验。
3. A structured simple form for ordering genetic tests is needed to ensure coupling of clinical detail (phenotype) with DNA variants (genotype) to ensure utility in publication and databases. [J] . Cotton RG, Auerbach AD, Brown AF, Human mutation . 2007,第10期

机译：需要一种结构简单的表格来订购基因测试，以确保临床细节（表型）与DNA变体（基因型）的结合，以确保在出版物和数据库中的实用性。
4. Feasibility of Using Clinical Element Models (CEM) to Standardize Phenotype Variables in the Database of Genotypes and Phenotypes (dbGaP) [C] . Lin Ko-Wei, Tharp Melissa, Conway Michael, 2012 IEEE Second International Conference on Healthcare Informatics, Imaging and Systems Biology. . 2012

机译：使用临床元素模型（CEM）标准化基因型和表型数据库（dbGaP）中的表型变量的可行性
5. Statistical methods to address the challenges posed by rare variants and missing genotypes in case-control resequencing studies. [D] . Kinnamon, Daniel Davis. 2013

机译：在病例对照重测序研究中，统计方法可应对稀有变异和基因型缺失所带来的挑战。
6. CYP2D6 Genotyping as an alternative to phenotyping for determination of metabolic status in a clinical trial setting [O] . Suzin McElroy, Jodi Richmond, Maruja Lira, 2000

机译：CYP2D6基因分型可替代表型用于在临床试验中确定代谢状态
7. CYP2D6 Genotyping as an alternative to phenotyping for determination of metabolic status in a clinical trial setting [O] . McElroy, Suzin, Richmond, Jodi, Lira, Maruja, 2000

机译：CYP2D6基因分型可替代表型，用于在临床试验中确定代谢状态

Challenges in clinical implementation of CYP2D6 genotyping: choice of variants to test affects phenotype determination

著录项

相似文献

相关主题

期刊订阅