P-732: Evaluation of muscle ageing by quadricipital echography

摘要

Introduction: Sarcopenia is defined as the combination of a substantial loss of muscle mass and functionality (strength and/or physical performance) with aging [1]. Our objective was to study the contribution of quadricipital muscle echography (rectus femoris) in the diagnosis of muscle ageing, in a healthy adult population participant from the EIT Health CHRONOS project. Method: Healthy and physically active volunteers (categories 2 and 3 in the International Physical Activity Questionnaire long version [2]) equally distributed between sexes and decades from 25 to 75 years of age performed a handgrip strength measure (dynamometer Jamar~?), an evaluation of physical performance using the Short Physical Performance Battery (SPPB), a 6 minute walk test and a 3-day diet record. Their body composition was assessed by dual-energy X-ray absorptiometry and echography of the rectus femoris muscle. Results: The 82 physically active volunteers had an average age of 49 ± 14 years and a body mass index (BMI) of 23.7 ± 2.7 kg/m~2. Their BMI, physical activity level, dietary intake (in kilocalories/ kg/day and protein/kg/day) and comorbidity level (Charlson score) did not differ from each other between the 5 decades. Their skeletal muscle mass index, grip strength, SPPB, and walking distance did not differ between age groups. The muscle thickness of the rectus femoris decreased with age from 20.0 ± 2.4 mm between 25-34 years to 15.9 ±1.1 mm between 65-75 years (p < 0.001). In contrast, ultrasound subcutaneous fat thickness increased between 25-34 years and 65-75 years (4.0 ± 1.1 vs. 6.2 ± 1.4 mm, p < 0.001). Key conclusion: Quadriceps muscle echography is non-invasive and more sensitive tool than DEXA to detect changes in muscle aging.