Outcomes of patients with intermediate risk early stage cervical adenocarcinoma - a single institution experience

摘要

Purpose of investigation: To assess the treatment efficacy in FIGO Stage I AC (adenocarcinoma, AC) patients with a special focus on treatment failure. Materials and Methods: Among 93 patients with AC of the uterine cervix, 33 patients with FIGO Stage I were treated with radical hysterectomy (RH) and adjuvant treatment, according to the presence of risk factors in the histopathology protocol. Results: The median follow-up after treatment was 61 (range: 7-96) months. Recurrence developed in six (18%) of the 33 patients; two died of cervical cancer. In three cases (9%), recurrence was outside the pelvis and in three (9%) loco-regional recurrence was confirmed. All recurrences occurred in the intermediate and high-risk group. Conclusion: Outcomes of patients with intermediate risk factors in early cervical AC treated with surgery and adjuvant radiotherapy (RT) are unsatisfactory. The studies confirming how patients with intermediate risk factors may benefit from adjuvant chemoradiotherapy (CRT) seem to be necessary.