Association of myeloperoxidase-463G>A polymorphism with cervical cancer in Chinese Han women

摘要

Objective: Myeloperoxidase (MPO) is an endogenous oxidant in neutrophilic and monocytic cytoplasmic granules. Several epidemiological studies indicate that MPO genetic polymorphisms are associated with cancer risk. Thus the present assessed an association between the MPO-463G>A polymorphism and cervical cancer risk in Chinese Han women. Materials and Methods: A hospital-based case-control study included 276 Chinese Han patients with cervical cancer and 284 age-, and ethnic-matched controls. The MPO-463G>A polymorphism was analyzed with PCR-restriction fragment length polymorphism (RFLP). Associations between the MPO polymorphism and cervical cancer risk were confirmed with x(2) tests. Results: No significant differences occurred among genotype distributions of the MPO-463G>A polymorphism between patients and controls. In a subgroup analysis of cervical cancer patients, there was no association between the MPO polymorphism and cervical cancer histological types or grades or tumor stage. Conclusions: The MPO-463G>A polymorphism is not associated with a risk of cervical cancer in Chinese Han women.