miR27a AG miR423 CA miR449b AG miR604 AG Association of miR27a AG miR423 CA miR449b AG and miR604 AG single nucleotide polymorphism with the risk of recurrent implantation failure in a Korean women

摘要

The present invention relates to a correlation between miR-27a AG (rs895819), miR-423 C A (rs6505162), miR-449b A G (rs10061133) and miR-604 A G (rs2368393) single nucleotide polymorphisms and a risk of recurrent implantation failures among Korean women and, more particularly, to a method and kit for distinguishing a single nucleotide polymorphism selected from miR-27a A G, miR-449b A G and miR-604 A G from a subject′s DNA sample or further distinguishing a single nucleotide polymorphism of miR-423 C A to provide information required for predicting a risk of developing recurrent implantation failures among Korean women. According to the present invention, it is possible to provide information very useful in predicting a risk of developing recurrent implantation failures among Korean women by distinguishing a single nucleotide polymorphism selected from miR-27a A G, miR-449b A G and miR-604 A G from a subject′s DNA sample or further distinguishing a single nucleotide polymorphism of miR-423 C A to provide information required for predicting a risk of developing recurrent implantation failures among Korean women. In particular, in case of using the kit of the present invention using the single nucleotide polymorphism, it is possible to more easily provide the above information.