Study of Serum Lipid Profile in Normal Pregnancy

摘要

Background: Normal pregnancy is a state of insulin resistance (IR). Purpose of insulin resistance adapted by mother is to deliver enough quantity of nutrients to the growing fetus. Elevated IR may cause dyslipidemic changes in maternal lipid profile.Aim : The study aims at evaluating serum lipid profile at different trimesters of pregnancy.Methods: Pregnant women at 1~(st), 2~(nd) and 3~(rd) trimester were divided into groups I, II and III respectively (n=20 in each group). Healthy non-pregnant women were taken as controls (n=30). Serum lipid profile was estimated from fasting serum sample using commercially available kits. The student's t-test and one way ANOVA were used for data analysis.Results: The mean levels of serum triglycerides, total cholesterol, LDL were significantly higher in 2~(nd) and 3~(rd) trimesters while HDL was significantly lower in 2~(nd) and 3~(rd) trimesters of pregnancy when compared with controls.