Renal infarction in hypereosinophilic syndrome

摘要

We report a case of renal infarction causing significant morbidity in hypereosinophilic syndrome (HES) in a 42-year-old man that resolved with the escalation of immunomodulatory therapy. This is one of a few cases in the literature to date describing in situ renal artery thrombosis in HES, suggesting that the pathogenesis of the thrombosis is at least in part related to damage from activated eosinophils. The diagnosis of HES was secured on the basis of fever, rash and persistent eosinophilia (>1.5 x 10~9 cells/L) for more than 6 months. His bone marrow biopsy revealed an increased number of eosinophils and eosinophil precursors (20% of cells), and transcripts for FIP1-L1-PDGFRA and bcr-abl were negative. Other causes of hypereosinophilia were excluded.