Microwave-assisted Solvent-free Synthesis and Antibacterial Activity of 6-Aryl-8-(4-methoxyphenyl)-8,11-dihydropyrazolo[3',4':4,5]pyrimido[1,2-a][1,8] naphthyridin-11-ones

摘要

A simple and efficient method for the synthesis of 6-aryl-8-(4-methoxyphenyl)-8,11-dihydropyrazolo[3',4':4,5] pyrimido[1,2-a][1,8]naphthyridin-11-ones 3 by the cyclocondensation of 3-aryl-2-chloro-1,8-naphthyridines 1 with 5-amino-1-(4-methoxyphenyl)-1H-pyrazole-4-carboxylic acid 2 in the presence of a catalytic amount of DMF in solvent-free conditions under microwave irradiation has been described. The reaction proceeds efficiently in high yields and a state of excellent purity. The structures of compounds 3 are assigned on the basis of their spectral (IR, H-1 nuclear magnetic resonance and MS) and analytical data. The compounds 3 have been evaluated for their antibacterial activity.