SYNTHESIS AND ANTICANCER ACTIVITY OF NOVEL 2-BENZYL-6-(SUBSTITUTED PHENYL)-IMIDAZO[2,1-B] [1,3,4] THIADIAZOLE DERIVATIVES

摘要

A new series of 2-benzyl-6-(substituted phenyl)-imidazo[2,1-b][1,3,4] thiadiazoles (S1-S8) was synthesized as potential anti-cancer agents. These compounds were evaluated for their anticancer activity against various cancer cell lines. The anticancer activity data reveals that the compounds S1 (2-benzyl-6-phenylimidazo[2,1-b][1,3,4]thiadiazole) showed maximum growth inhibition against CNS cancer cell lines while the compounds S2 (2-benzyl-6-(4-chlorophenyl) imidazo[2,1-b][1,3,4] thiadiazole) and S3 (2-benzyl-6-(2,4-dichlorophenyl)imidazo[2,1-b][1,3,4] thiadiazole) showed maximum inhibition against leukemia cell lines. The compounds S5 (2-(2-benzylimidazo[2,1 -b] [1,3,4]thiadiazol-6-yl) phenol) and S6 (4-(2-benzylimidazo[2,1-b][1,3,4] thiadiazol-6-yl)benzene-1,3-diol) showed maximum inhibition against renal cancer cell lines and the compound S7 (3-(2-benzylimidazo[2,1-b][1,3,4] thiadiazol-6-yl) ben-zenamine) was most active against non-small cell lung cancer cell lines.