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6-PHENYL-2-Ý((PIPERIDIN-4-YLMETHYL)-PIPERAZIN-1YL) OR PIPERAZIN 1-YLMETHYL)-PIPERIDIN-1-YL)¨-IMIDAZOÝ2,1-B¨Ý1,3,4¨THIADIAZOLE DERIVATIVES AND THEIR USE
6-PHENYL-2-Ý((PIPERIDIN-4-YLMETHYL)-PIPERAZIN-1YL) OR PIPERAZIN 1-YLMETHYL)-PIPERIDIN-1-YL)¨-IMIDAZOÝ2,1-B¨Ý1,3,4¨THIADIAZOLE DERIVATIVES AND THEIR USE
Heterocyclic compounds of formula (I), (II), (III) or a pharmaceutically acceptable salt thereof: wherein R1, R2 and R3 are each independently selected from hydrogen, halogen, C1-6alkyl, C2-6alkenyl, N-(C1-6alkyl)2, and N-(C2-6alkenyl)2, the C1-6alkyl and C2-6alkenyl being straight or branched; and Y1 and Y2 are selected from N and CH where one of Y1 and Y2 is N and the other is CH, are provided. Also provided are the synthesis of and pharmaceutical compositions including these compounds. These compounds and pharmaceutical compositions thereof can be used for the treatment of disorders, and in particular, cancer.
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机译:式(I),(II),(III)的杂环化合物或其药学上可接受的盐:其中R 1,R 2和R 3各自独立地选自氢,卤素,C 1-6烷基,C 2-6烯基,N-(C 1- C 1-6烷基和C 2-6烯基为直链或支链的; C 6-6烷基)2和N-(C 2-6烯基)2。并从N和CH中选择Y1和Y2,其中Y1和Y2之一为N,另一个为CH。还提供了包括这些化合物的药物组合物的合成。这些化合物及其药物组合物可用于治疗疾病,尤其是癌症。
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