Synthesis of some new 2,4-diaryl-2,3-dihydro-1,5-benzothiazepines and 2-aryl-4-(2'-hydroxy-3'/5'-chloro-5'/3'-hydroxymethylphenyl)-2,3-dihydro-1,5-benzothiazepines.

摘要

The title compounds 2a,b have been synthesized from the corresponding,1-(2'-hydroxy-3'/5'-chloro-5'/3'-hydroxy methyl-phenyl)-3-aryl-2-propen-1-ones (1)by condensation with o-aminothiophenol in ethanol containg a few drops of piperidine followed by cycli-sation in the presence of acetic acid. Some of the representative members have been screened for their antifungal activity against Penicillium notatum. In general, the cmpounds have been found to be stimulatory against Penicillium notatum.