Lupus Low Disease Activity State (LLDAS) attainment discriminates responders in a systemic lupus erythematosus trial: post-hoc analysis of the Phase IIb MUSE trial of anifrolumab

Morand Eric F.; Trasieva Teodora; Berglind Anna; Illei Gabor G.; Tummala Raj

首页> 外文期刊>Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research >Lupus Low Disease Activity State (LLDAS) attainment discriminates responders in a systemic lupus erythematosus trial: post-hoc analysis of the Phase IIb MUSE trial of anifrolumab

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Lupus Low Disease Activity State (LLDAS) attainment discriminates responders in a systemic lupus erythematosus trial: post-hoc analysis of the Phase IIb MUSE trial of anifrolumab

机译：Lupus低疾病活动状态（LLDAS）达到判断在Systemic狼疮红斑试验中的响应者判断：HOC对ANIFROLUMAB的IIB MUSE试验的后HOC分析

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Objectives In a post-hoc analysis, we aimed to validate the Lupus Low Disease Activity State (LLDAS) definition as an endpoint in an systemic lupus erythematosus (SLE) Phase IIb randomised controlled trial (RCT) (MUSE [NCT01438489]) and then utilize LLDAS to discriminate between anifrolumab and placebo.

机译：在HOC分析中的目标，我们旨在验证狼疮低疾病活动状态（LLDAS）定义作为系统性狼疮红斑（SLE）IIB随机对照试验（RCT）（MUSE [NCT01438489]）中的终点，然后利用 LLDAS歧视Anifrolumab和安慰剂。

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《Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research》 |2018年第5期|共8页
作者
Morand Eric F.; Trasieva Teodora; Berglind Anna; Illei Gabor G.; Tummala Raj;
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Monash Univ Ctr Inflammatory Dis Melbourne Vic Australia;

AstraZeneca Gothenburg Sweden;

AstraZeneca Gothenburg Sweden;

MedImmune LLC Gaithersburg MD USA;

AstraZeneca Gaithersburg MD USA;

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正文语种 eng
中图分类免疫性疾病;
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1. Comment on: ‘Lupus Low Disease Activity State (LLDAS) attainment discriminates responders in a systemic lupus erythematosus trial: post-hoc analysis of the Phase IIb MUSE trial of anifrolumab’ by Eric Morand et al [J] . David Isenberg Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2019,第11期

机译：评论：'狼疮低疾病活动状态（LLDAS）达到判断在Systemic Lupus红斑试验中判断响应者：Heacer MustAns的IIB缪斯缪斯试验后的HOC分析
2. Lupus Low Disease Activity State (LLDAS) attainment discriminates responders in a systemic lupus erythematosus trial: post-hoc analysis of the Phase IIb MUSE trial of anifrolumab [J] . Morand Eric F., Trasieva Teodora, Berglind Anna, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2018,第5期

机译：Lupus低疾病活动状态（LLDAS）达到判断在Systemic狼疮红斑试验中的响应者判断：HOC对ANIFROLUMAB的IIB MUSE试验的后HOC分析
3. Response to: ‘Comment on: ‘Lupus Low Disease Activity State(LLDAS) attainment discriminates responders in a systemic lupus erythematosus trial: post-hocanalysis of the Phase IIb MUSE trial of anifrolumab’ by Eric Morand et al’ by Isenberg [J] . Eric F Morand, Teodora Trasieva, Anna Berglind, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2019,第11期

机译：回应：'评论：'狼疮低疾病活动状态（LLDAS）达到判断在系统性红斑狼疮试验中的响应者：伊森伯格埃里克·莫兰等人的IIB缪斯试验后术后
4. Serum Levels of Leptin in Patients with Systemic Lupus Erythematosus: Correlated with Lupus Activity [C] . XU Ting, JIN Ou-yang, ZHAO Sheng-nan, International Forum on Progress on Post-Genome Technologies(5'IFPT); 20070910-11; Suzhou(CN) . 2007

机译：系统性红斑狼疮患者血清瘦素水平：与狼疮活动相关
5. Investigation of the relationship between disease activity and disease damage in childhood-onset systemic lupus erythematosus. [D] . Brunner, Hermine Isabella. 2001

机译：儿童期系统性红斑狼疮疾病活动与疾病损害之间关系的研究。
6. Extended report: Lupus Low Disease Activity State (LLDAS) attainment discriminates responders in a systemic lupus erythematosus trial: post-hoc analysis of the Phase IIb MUSE trial of anifrolumab [O] . Eric F Morand, Teodora Trasieva, Anna Berglind, -1

机译：扩展报告：系统性红斑狼疮试验中狼疮低病活动状态（LLDAS）的获得可区分反应者：对anifrolumab的IIb期MUSE试验的事后分析
7. Comment on: ‘Lupus Low Disease Activity State (LLDAS) attainment discriminates responders in a systemic lupus erythematosus trial: post-hoc analysis of the Phase IIb MUSE trial of anifrolumab’ by Eric Morand et al [O] . David Isenberg 2018

机译：评论：'狼疮低疾病活动状态（LLDAS）达到判断在系统性红斑狼疮试验中判断响应者：埃里克·莫兰等人的IIB缪斯缪斯试验后的HOC分析

Lupus Low Disease Activity State (LLDAS) attainment discriminates responders in a systemic lupus erythematosus trial: post-hoc analysis of the Phase IIb MUSE trial of anifrolumab

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