Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: results from the open-label period of a phase II randomised controlled trial (faSScinate)

Khanna Dinesh; Denton Christopher P.; Lin Celia J. F.; van Laar Jacob M.; Frech Tracy M.; Anderson Marina E.; Baron Murray; Chung Lorinda; Fierlbeck Gerhard; Lakshminarayanan Santhanam; Allanore Yannick; Pope Janet E.; Riemekasten Gabriela; Steen Virginia; Mueller-Ladner Ulf; Spotswood Helen; Burke Laura; Siegel Jeffrey; Jahreis Angelika; Furst Daniel E.

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Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: results from the open-label period of a phase II randomised controlled trial (faSScinate)

机译：皮下对系统性硬化症的安全性和有效性：II期随机对照试验的开放标签期（Fasscinate）的结果

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Objectives Assess the efficacy and safety of tocilizumab in patients with systemic sclerosis (SSc) in a phase II study.

机译：目的评估II期研究中Sysic硬化症患者托运中的毒素和安全性。

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来源
《Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research》 |2018年第2期|共9页
作者
Khanna Dinesh; Denton Christopher P.; Lin Celia J. F.; van Laar Jacob M.; Frech Tracy M.; Anderson Marina E.; Baron Murray; Chung Lorinda; Fierlbeck Gerhard; Lakshminarayanan Santhanam; Allanore Yannick; Pope Janet E.; Riemekasten Gabriela; Steen Virginia; Mueller-Ladner Ulf; Spotswood Helen; Burke Laura; Siegel Jeffrey; Jahreis Angelika; Furst Daniel E.;
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作者单位

Univ Michigan Scleroderma Program Ann Arbor MI 48109 USA;

UCL Sch Med London England;

Genentech Inc San Francisco CA 94080 USA;

Univ Med Ctr Utrecht Utrecht Netherlands;

Univ Utah Vet Affairs Med Ctr Salt Lake City UT USA;

Univ Liverpool Liverpool Merseyside England;

Jewish Gen Hosp Montreal PQ Canada;

Stanford Univ Sch Med Palo Alto CA 94304 USA;

Univ Tubingen Tubingen Germany;

Univ Connecticut Ctr Hlth Farmington CT USA;

Paris Descartes Univ Paris France;

Univ Western Ontario St Josephs Hlth Care Schulich Sch Med &

Dent London ON Canada;

Univ Lubek Berlin Germany;

Georgetown Univ Washington DC USA;

Justus Liebig Univ Giessen Kerckhoff Clin Bad Nauheim Germany;

Roche Prod Ltd Welwyn Garden City Herts England;

Roche Prod Ltd Welwyn Garden City Herts England;

Genentech Inc San Francisco CA 94080 USA;

Genentech Inc San Francisco CA 94080 USA;

Univ Calif Los Angeles Los Angeles CA USA;

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原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
关键词
systemic sclerosis (SSc); treatment; DMARDs (biologic); scleroderma; tocilizumab; interleukin-6;

机译：全身硬化（SSC）;治疗;DMARDS（生物学）;硬皮病;拍摄;白细胞介素-6;

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专利

1. Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: results from the open-label period of a phase II randomised controlled trial (faSScinate) [J] . Khanna Dinesh, Denton Christopher P., Lin Celia J. F., Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2018,第2期

机译：皮下对系统性硬化症的安全性和有效性：II期随机对照试验的开放标签期（Fasscinate）的结果
2. Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial (vol 387, pg 2630, 2016) [J] . Khanna D., Denton C. P., Jahreis Angelika A. The Lancet . 2018,第10128期

机译：皮下对硅酸盐在全身硬化症（土豆酸盐）中的安全性和有效性（土豆酸）：2阶段，随机，受控试验（Vol 387，PG 2630,2016）
3. Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial [J] . Khanna Dinesh, Denton Christopher P., Jahreis Angelika, The Lancet . 2016,第10038期

机译：成人系统性硬化症（faSScinate）皮下Tocilizumab的安全性和有效性：一项2期随机对照试验
4. An open-label, multicenter, randomized,comparative, safety, efficacy, cycle control,and quality of life study of CTR 25, Alesse ,and Ortho Tri-Cyclen [C] . Victoria Davis, Brian Hauck, Sheila Dunn, World Congress on Fertility and Sterility . 2004

机译：开放标签，多中心，随机，比较，安全，疗效，循环控制和CTR 25，Alesse和Ortho Tri-Cyclen的生命研究
5. Efficacy and safety of novel collagen conduits filled with collagen filaments to treat patients with peripheral nerve injury: A multicenter, controlled, open-label clinical trial [D] . Saeki Masaomi, 佐伯将臣 2019

机译：充满胶原细丝的新型胶原蛋白导管治疗周围神经损伤患者的疗效和安全性：一项多中心，对照，开放标签的临床试验
6. Extended report: Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: results from the open-label period of a phase II randomised controlled trial (faSScinate) [O] . Dinesh Khanna, Christopher P Denton, Celia J F Lin, -1

机译：扩展报告：皮下妥珠单抗在系统性硬化症中的安全性和有效性：II期随机对照试验（faSScinate）的开放标签期结果
7. Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: results from the open-label period of a phase II randomised controlled trial (faSScinate) [O] . Khanna, D, Denton, CP, Lin, CJ, 2017

机译：皮下妥珠单抗在系统性硬化中的安全性和有效性：II期随机对照试验（faSScinate）的开放标签期得出的结果

Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: results from the open-label period of a phase II randomised controlled trial (faSScinate)

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