Comparative Assessment of Serum Adipokines Zinc-α2-glycoprotein and Adipose Triglyceride Lipase, and Cardiovascular Risk Factors Between Normal Weight and Obese Patients with Hemodialysis

摘要

Background Little is known about the potential relationship of obesity, adipose tissue and novel adipokines with cardiometabolic risk factors in end-stage renal disease. Zinc-α2-glycoprotein (ZAG) and adipose triglyceride lipase (ATGL) are novel adipokines with proposed desirable effects on inflammation, and lipid and glucose metabolism. The aim of this study was to investigate serum concentrations of ZAG and ATGL, and the relationship of these adipokines with cardiovascular risk factors in normal weight (NW) and obese (OB) patients undergoing hemodialysis. Methods Patients with regular hemodialysis including 44 normal weight (18.5 2 ) and 44 obese (BMI≥30?kg/m 2 ) were enrolled. Serum lipid profile, high-sensitivity C-reactive protein (hsCRP) and nitric oxide metabolites along with ZAG and ATGL concentrations were assessed. Results ZAG concentrations were significantly lower in OB compared to NW group (100?±?34 vs. 106?±?31?ng/ml; p ?=?0.007). No significant difference was observed in ATGL between the two groups. A significant inverse correlation between ZAG and HDL ( r ?=??0.236, p ?=?0.048) and a marginal inverse correlation between ATGL and HDL ( r ?=??0.211, p ?=?0.078) were observed in all patients. ZAG had positive correlations with triglyceride/HDL ( r ?=?0.279, p ?=?0.019), cholesterol/HDL ( r ?=?0.319, p ?=?0.007), and LDL/HDL ( r ?=?0.26, p ?=?0.029) ratios. Among cardiovascular risk factors, only LDL/HDL ratio and hsCRP were significantly higher in OB patients ( p ?=?0.009 and p ?=?0.038, respectively). Conclusions Serum concentrations of ZAG, but not ATGL, were significantly lower in the OB group. It appears that obesity overrides the role of hemodialysis in determining ZAG concentration. In contrast, uremic condition might overshadow the role of obesity in determining levels of traditional cardiovascular risk factors.