Novel sulfamate derivatives of menthol: Synthesis, characterization, and cholinesterases and carbonic anhydrase enzymes inhibition properties

摘要

Abstract Sulfamates have a large spectrum of biological activities including enzyme inhibition. Eight sulfamates derived from menthol ( 2a–h ) were synthesized. Also, in the other section of this study, novel sulfamate derivatives of menthol were tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carbonic anhydrase I and II enzymes (hCAs I and II). The newly synthesized novel menthol sulfamate and menthol carbonyl sulfamate derivatives showed K i values in the range of 34.37?±?8.17 to 53.40?±?10.61?nM against hCA I, 12.91?±?4.57 to 38.67?±?6.22?nM against hCA II, 111.17?±?52.36 to 522.86?±?120.08?nM against AChE, and 50.01?±?11.73 to 109.63?±?50.08?nM against BChE. As a result, the novel menthol sulfamate and menthol carbonyl sulfamate derivatives can be promising Alzheimer's disease drug candidates and novel hCA I and hCA II enzymes inhibitors.