Novel Screening Paradigms for the Identification of Allosteric Modulators and/or Biased Ligands for Challenging G-Protein-Coupled Receptors

Schann Stephan; Neuville Pascal; Bouvier Michel

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Novel Screening Paradigms for the Identification of Allosteric Modulators and/or Biased Ligands for Challenging G-Protein-Coupled Receptors

机译：用于鉴定抗原性调节剂和/或偏置配体的新型筛选范式，用于挑战G蛋白偶联受体

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《Annual reports in medicinal chemistry.》 |2014年第null期|共16页
作者
Schann Stephan; Neuville Pascal; Bouvier Michel;
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Domain Therapeut SA Strasbourg France;

Domain Therapeut SA Strasbourg France;

Univ Montreal Dept Biochem Inst Res Immunol &

Canc Montreal PQ H3C 3J7 Canada;

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原文格式 PDF
正文语种 eng
中图分类药学;
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1. Novel Screening Paradigms for the Identification of Allosteric Modulators and/or Biased Ligands for Challenging G-Protein-Coupled Receptors [J] . Schann Stephan, Neuville Pascal, Bouvier Michel Annual reports in medicinal chemistry. . 2014,第Null期

机译：新颖的筛选范式，用于识别具有挑战性的G蛋白偶联受体的变构调节剂和/或偏向配体。
2. Strategies for the identification of allosteric modulators of G-protein-coupled receptors. [J] . Burford NT, Watson J, Bertekap R, Biochemical Pharmacology . 2011,第6期

机译：鉴定G蛋白偶联受体的变构调节剂的策略。
3. Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors [J] . Southern C., Cook J.M., Neetoo-Isseljee Z., Journal of biomolecular screening: The official journal of the Society for Biomolecular Screening . 2013,第5期

机译：筛选β-arrestin募集以鉴定孤儿G蛋白偶联受体的天然配体
4. An efficient and rational method for selecting allosteric modulators to GABAA receptors using ligand-directed chemistry [C] . Kei Yamaura, Shigeki Kiyonaka, Seiji Sakamoto 日本化学会春季年会講演予稿集 . 2018

机译：用配体导化学选择颠覆调节剂对GABAA受体的高效合理方法
5. Identification and characterization of a novel positive allosteric modulator of alpha 7 nicotinic acetylcholine receptors with therapeutic potential in schizophrenia [D] . Ng, Herman Jen 2007

机译：新型精神病性精神分裂症的α7烟碱乙酰胆碱受体的新型变构调节剂的鉴定与表征
6. Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening [O] . Cassandra Koole, Denise Wootten, John Simms, -1

机译：胰高血糖素样肽1受体（GLP-1R）的变构配体差异地调节内源性和外源性肽反应的途径选择性方式：对药物筛选的影响。
7. “Selective” Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands [O] . Shane D. Hellyer, Sabine Albold, Taide Wang, 2018

机译：“选择性”类C g蛋白偶联受体调节剂是中性或偏置Mglu5变构配体
8. Identification of G-Protein-Coupled Receptors (GPCRs) in Pulmonary Artery Smooth Muscle Cells as Novel Therapeutic Targets. [R] . Insel, P. 2017

机译：鉴定肺动脉平滑肌细胞中G蛋白偶联受体（GpCR）作为新的治疗靶标。

Novel Screening Paradigms for the Identification of Allosteric Modulators and/or Biased Ligands for Challenging G-Protein-Coupled Receptors

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