;wherein Z is a template-fixed chain of 8 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly or Pro or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have agonizing or antagonizing activity against urotensin II or show inhibition of the STAT6/NCoA-1 interaction and can be used for preventing or treating diseases or disorders related to urotensin II, STAT6 and NCoA-1.;These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy."/>
公开/公告号US2017369523A1
专利类型
公开/公告日2017-12-28
原文格式PDF
申请/专利权人 POLYPHOR AG;
申请/专利号US201715701284
发明设计人 JOHN ANTHONY ROBINSON;KERSTIN MÖHLE;MARKUS SEITZ;LUDOVIC T. MAILLARD;ROBA MOUNME;FRANK OTTO GOMBERT;ODILE SELLIER-KESSLER;HEIKO HENZE;DANIEL OBRECHT;CHRISTIAN BISANG;ALEXANDER LEDERER;
申请日2017-09-11
分类号C07K1/02;C07K7/64;C07K7/56;
国家 US
入库时间 2022-08-21 13:01:55