Mechanistic Debris Generated by Twister Ribozymes

摘要

Twister RNAs represent a recently discovered class of natural ribozymes that promote rapid cleaving of RNA backbones. Although an abundance of theoretical, biochemical, and structural data exist for several members of the twister class, disagreements about the architecture and mechanism of its active site have emerged. Historically, such storms regarding mechanistic details typically occur soon after each pew self-cleaving ribozyme class is reported, but paths forward exist to quickly reach calmer conditions.