Optimizing the Method for Authenticating Pharmaceutical Products of Different Dosage Forms Using Dual Laser Handheld Raman Spectroscopy

摘要

Handheld Raman spectroscopy has emerged over the last few years as a rapid technique for authenticating medicines. Major challenges arose in the authentication process attributed to the Raman activity of the main constituents or to the formulation type. This witnessed the masking of the Raman signal of herbal medicinal products or medicinal products of low dosage forms. Liquid and semisolid formulations represented a further challenge in the authentication process which was mainly attributed to the number of soluble/ insoluble constituents. The present work aims to optimize the method for authenticating medicinal products of different dosage forms using dual laser handheld Raman spectroscopy.