Utility of Cyclin D1 in the Diagnostic Workup of Hematopoietic Neoplasms: What Can Cyclin D1 Do for Us?

Wang Wei; Medeiros L. Jeffrey

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Utility of Cyclin D1 in the Diagnostic Workup of Hematopoietic Neoplasms: What Can Cyclin D1 Do for Us?

机译：细胞周期蛋白D1在造血肿瘤诊断上的效用：Cyclin D1可以为我们做什么？

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摘要

Cyclin D1, encoded by CCND1, promotes cell cycle progression from G1 to S phase. Its expression is induced by MAPK/ERK pathway as well as translocations/rearrangements involving CCND1 gene. The evaluation of cyclin D1 expression by immunohistochemistry plays an important role in the diagnostic workup of various hematopoietic diseases. In this review, we aimed to discuss the value of cyclin D1 immunostain in the diagnosis and different diagnosis of hematopoietic neoplasms.

机译：CCND1编码的细胞周期蛋白D1促进从G1到S相的细胞周期进展。其表达由MAPK / ERK途径和涉及CCND1基因的易位/重排。免疫组织化学对细胞周期蛋白D1表达的评价在各种造血疾病的诊断次数中起重要作用。在本综述中，我们旨在讨论细胞周期蛋白D1免疫抑制在造血肿瘤的诊断和不同诊断中的价值。

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来源
《Advances in anatomic pathology》 |2019年第5期|共11页
作者
Wang Wei; Medeiros L. Jeffrey;
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作者单位

Univ Texas MD Anderson Canc Ctr Dept Hematopathol Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Hematopathol Houston TX 77030 USA;

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原文格式 PDF
正文语种 eng
中图分类病理学;
关键词
cyclin D1; hematopoietic neoplasms; differential diagnosis;

机译：细胞周期蛋白D1;造血肿瘤;鉴别诊断;

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1. Utility of Cyclin D1 in the Diagnostic Workup of Hematopoietic Neoplasms: What Can Cyclin D1 Do for Us? [J] . Wang Wei, Medeiros L. Jeffrey Advances in anatomic pathology . 2019,第5期

机译：细胞周期蛋白D1在造血肿瘤诊断上的效用：Cyclin D1可以为我们做什么？
2. Diagnostic utility of cyclin D1 in the diagnosis of small round blue cell tumors in children and adolescents: beware of cyclin D1 expression in clear cell sarcoma of the kidney and CIC-DUX4 fusion–positive sarcomas. Comment on Magro et al (2016) [J] . David Creytens, Liesbeth Ferdinande, Jo Van Dorpe Human Pathology . 2017,第期

机译：细胞周期蛋白D1在儿童和青少年小圆形蓝细胞肿瘤诊断中的诊断效用：小组蛋白D1在肾脏和CIC-Dux4融合阳性肉瘤中的Cyclin D1表达。关于Magro等人（2016）的评论
3. D cyclins in CD5+ B-cell lymphoproliferative disorders: cyclin D1 and cyclin D2 identify diagnostic groups and cyclin D1 correlates with ZAP-70 expression in chronic lymphocytic leukemia. [J] . Meyerson HJ, MacLennan G, Husel W, American journal of clinical pathology. . 2006,第2期

机译：CD5 + B细胞淋巴增生性疾病中的D细胞周期蛋白：细胞周期蛋白D1和细胞周期蛋白D2鉴定诊断组，细胞周期蛋白D1与慢性淋巴细胞白血病中ZAP-70的表达相关。
4. The Expression of ß-catenin, CyclinD1 and C-myc mRNA on Thymus Tissue Exposed Irradiation [C] . Wang Hong-Yan, Chen Yu-Bing, Gong Shou-Liang, Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on . 2012

机译：ß-catenin，CyclinD1和C-myc mRNA在胸腺组织照射下的表达
5. Diverse functions for cyclins D1 and D2 in neuronal progenitors and post-mitotic neurons in the adult brain [D] . Koeller, Hajira Begum 2008

机译：成年大脑中神经元祖细胞和有丝分裂后神经元中细胞周期蛋白D1和D2的多种功能
6. Immunohistochemical Analysis of Cyclin D1 Protein in Hematopoietic Neoplasms with Special Reference to Mantle Cell Lymphoma [O] . Shigeo Nakamura, Masao Seto, Shogo Banno, 1994

机译：免疫细胞化学分析Cyclin D1蛋白在造血肿瘤中特别涉及套细胞淋巴瘤。
7. D Cyclins in CD5+ B-Cell Lymphoproliferative Disorders: Cyclin D1 and Cyclin D2 Identify Diagnostic Groups and Cyclin D1 Correlates With ZAP-70 Expression in Chronic Lymphocytic Leukemia [O] . Howard J. Meyerson, Grayden MacLennan, William Husel, 2006

机译：CD5 + B细胞淋巴抑制性疾病中的C周期蛋白：Cyclin D1和Cyclin D2鉴定诊断基团和细胞周期蛋白D1与慢性淋巴细胞白血病中的ZAP-70表达相关

Utility of Cyclin D1 in the Diagnostic Workup of Hematopoietic Neoplasms: What Can Cyclin D1 Do for Us?

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