Comparative Effectiveness of Newer Tyrosine Kinase Inhibitors Versus Imatinib in the First-Line Treatment of Chronic-Phase Chronic Myeloid Leukemia Across Risk Groups: A Systematic Review and Meta-Analysis of Eight Randomized Trials

摘要

The goal of the present study was to compare the outcomes of new generation tyrosine kinase inhibitors (NG-TKIs) versus imatinib in patients with newly diagnosed chronic phase chronic myeloid leukemia and to assess the effect of the risk scores on the treatment response. NG-TKIs resulted in a greater major molecular response, and the degree of benefit from NG-TKIs on the complete cytogenetic response and major molecular response was equivalent across the risk groups.