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首页> 外文期刊>Cytokine >Association between high levels of inflammatory markers and cognitive outcomes at 4 years of age: The Rhea mother-child cohort study, Crete, Greece
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Association between high levels of inflammatory markers and cognitive outcomes at 4 years of age: The Rhea mother-child cohort study, Crete, Greece

机译：4岁的高水平炎症标志物和认知结果之间的关联：瑞亚母儿童队列研究，克里特岛，希腊

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摘要

There is growing evidence associating inflammatory markers in complex, higher order neurological functions, such as cognition and memory. We examined whether high levels of various inflammatory markers are associated with cognitive outcomes at 4 years of age in a mother-child cohort in Crete, Greece (Rhea study). We included 642 children in this cross-sectional study. Levels of several inflammatory markers (IFN-gamma, IL-1 beta, IL-6, IL-8, IL-17 alpha, IL-10, MIP-1 alpha, TNF-alpha and the ratios of IL-6 to IL-10 and TNF-alpha to IL-10) were determined in child serum via immunoassay. Neurodevelopment at 4 years was assessed by means of the McCarthy Scales of Children's Abilities. Multivariate linear regression analyses were used to estimate the associations between the exposures and outcomes of interest after adjustment for various confounders. Our results indicate that children with high TNF-alpha concentrations (>= 90th percentile) in serum demonstrated decreased scores in memory (adjusted beta = 4.0; 95% CI: -7.7, -0.2), working memory (adjusted beta = -4.0; 95% CI: -8.0, -0.1) as well as in memory span scale (adjusted beta = -4.0; 95% CI: -7.9, -0.1). We also found that children with high IFN-gamma serum levels showed lower scores in memory span scale (adjusted beta = -3.4; 95% CI: -7.3, -0.4). Children with elevated TNF-alpha/IL-10 ratio demonstrated decreased quantitative (adjusted beta = -4.3; 95% CI: -8.2, -0.4), motor (adjusted beta = -3.5; 95% CI: -7.5, -0.5), executive function (adjusted beta = -4.8; 95% CI: -8.5, -1.1), general cognitive (adjusted beta = -3.6; 95% CI: -7.3, -0.1), memory (adjusted beta = -3.8; 95% CI: -7.6, -0), working memory (adjusted beta = -3.5; 95% CI: -7.5, -0.5) and memory span scores (adjusted beta = -5.3; 95% CI: -9.1, -1.4) The findings suggest that high levels of TNF-alpha may contribute to reduced memory performance at preschool age.
机译：越来越多的证据将炎症标志物在复杂的高阶神经功能，例如认知和记忆中相关。我们检查了在希腊克里特郡的母儿童队（Rhea Shorts）中4岁的4岁儿童的认知结果是否与认知结果有关。我们在这个横断面研究中包括642名儿童。几种炎症标记物（IFN-Gamma，IL-1β，IL-6，IL-8，IL-17α，IL-10，MIP-1α，TNF-α和IL-6的比例为IL-在儿童血清中通过免疫测定测定10和TNF-α至IL-10。通过麦卡锡的能力的麦卡锡评估评估了4年的神经发育。多变量线性回归分析用于估计调整各种混淆后兴趣的暴露和结果之间的关联。我们的研究结果表明，血清中具有高TNF-α浓度（> =第90百分位）的儿童证明了内存分数下降（调整后的β= 4.0; 95％CI：-7.7，-0.2），工作记忆（调整的BETA = -4.0; 95％CI：-8.0，-0.1）以及记忆跨度刻度（调整的beta = -4.0; 95％CI：-7.9，-0.1）。我们还发现，具有高IFN-Gamma血清水平的儿童在记忆跨度刻度中显示出较低的分数（调节的β= -3.4; 95％CI：-7.3，-0.4）。具有升高的TNF-α/ IL-10比率的儿童证明了定量降低（调节β= -4.3; 95％CI：-8.2，-0.4），电机（调整的β= -3.5; 95％CI：-7.5，-0.5） ，执行功能（调整β= -4.8; 95％CI：-8.5，-1.1），一般认知（调整β= -3.6; 95％CI：-7.3，-0.1），记忆（调整的Beta = -3.8; 95 ％CI：-7.6，-0），工作内存（调整β= -3.5; 95％CI：-7.5，-0.5）和内存跨度分数（调整β= -5.3; 95％CI：-9.1，-1.4）研究结果表明，高水平的TNF-alpha可能有助于降低学龄前的年龄的记忆性能。

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