UHPLC Quantitation Method and In vitro Studies of Two New Phthalimide Derivatives Planned to Treat Sickle Cell Disease

摘要

Background: Sickle cell disease is characterized by the occurrence of acute disability and progressive organ damage, and it is one of the most common and severe monogenic disorders around the world. Since hydroxycarbamide is the only drug approved by the Food and Drug Administration (FDA) to treat this disease, it is necessary to continue the development of new drug candidates to improve its treatment. Two of a series of phthalimide derivatives have shown great potential as a new drug candidate.